Regulation of Signal Transduction by Glutathione Transferases
المؤلفون المشاركون
Morel, Fabrice
Aninat, Caroline
Pajaud, Julie
Kumar, Sandeep
Rauch, Claudine
المصدر
International Journal of Hepatology
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-10-09
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Glutathione transferases (GST) are essentially known as enzymes that catalyse the conjugation of glutathione to various electrophilic compounds such as chemical carcinogens, environmental pollutants, and antitumor agents.
However, this protein family is also involved in the metabolism of endogenous compounds which play critical roles in the regulation of signaling pathways.
For example, the lipid peroxidation product 4-hydroxynonenal (4-HNE) and the prostaglandin 15-deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) are metabolized by GSTs and these compounds are known to influence the activity of transcription factors and protein kinases involved in stress response, proliferation, differentiation, or apoptosis.
Furthermore, several studies have demonstrated that GSTs are able to interact with different protein partners such as mitogen activated protein kinases (i.e., c-jun N-terminal kinase (JNK) and apoptosis signal-regulating kinase 1 (ASK1)) which are also involved in cell signaling.
New functions of GSTs, including S-glutathionylation of proteins by GSTs and ability to be a nitric oxide (NO) carrier have also been described.
Taken together, these observations strongly suggest that GST might play a crucial role during normal or cancer cells proliferation or apoptosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pajaud, Julie& Kumar, Sandeep& Rauch, Claudine& Morel, Fabrice& Aninat, Caroline. 2012. Regulation of Signal Transduction by Glutathione Transferases. International Journal of Hepatology،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-448687
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pajaud, Julie…[et al.]. Regulation of Signal Transduction by Glutathione Transferases. International Journal of Hepatology No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-448687
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pajaud, Julie& Kumar, Sandeep& Rauch, Claudine& Morel, Fabrice& Aninat, Caroline. Regulation of Signal Transduction by Glutathione Transferases. International Journal of Hepatology. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-448687
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-448687
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر