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Regulation of Signal Transduction by Glutathione Transferases
Joint Authors
Morel, Fabrice
Aninat, Caroline
Pajaud, Julie
Kumar, Sandeep
Rauch, Claudine
Source
International Journal of Hepatology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-09
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Glutathione transferases (GST) are essentially known as enzymes that catalyse the conjugation of glutathione to various electrophilic compounds such as chemical carcinogens, environmental pollutants, and antitumor agents.
However, this protein family is also involved in the metabolism of endogenous compounds which play critical roles in the regulation of signaling pathways.
For example, the lipid peroxidation product 4-hydroxynonenal (4-HNE) and the prostaglandin 15-deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) are metabolized by GSTs and these compounds are known to influence the activity of transcription factors and protein kinases involved in stress response, proliferation, differentiation, or apoptosis.
Furthermore, several studies have demonstrated that GSTs are able to interact with different protein partners such as mitogen activated protein kinases (i.e., c-jun N-terminal kinase (JNK) and apoptosis signal-regulating kinase 1 (ASK1)) which are also involved in cell signaling.
New functions of GSTs, including S-glutathionylation of proteins by GSTs and ability to be a nitric oxide (NO) carrier have also been described.
Taken together, these observations strongly suggest that GST might play a crucial role during normal or cancer cells proliferation or apoptosis.
American Psychological Association (APA)
Pajaud, Julie& Kumar, Sandeep& Rauch, Claudine& Morel, Fabrice& Aninat, Caroline. 2012. Regulation of Signal Transduction by Glutathione Transferases. International Journal of Hepatology،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-448687
Modern Language Association (MLA)
Pajaud, Julie…[et al.]. Regulation of Signal Transduction by Glutathione Transferases. International Journal of Hepatology No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-448687
American Medical Association (AMA)
Pajaud, Julie& Kumar, Sandeep& Rauch, Claudine& Morel, Fabrice& Aninat, Caroline. Regulation of Signal Transduction by Glutathione Transferases. International Journal of Hepatology. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-448687
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448687