Prognostic Significance and Clinicopathological Associations of COX-2 SNP in Patients with Nonsmall Cell Lung Cancer
المؤلفون المشاركون
Vallböhmer, Daniel
Brabender, Jan
Grimminger, Peter P.
Schneider, Paul Magnus
Metzger, Ralf
Hölscher, Arnulf H.
Danenberg, Peter V.
Stöhlmacher, Jan
المصدر
العدد
المجلد 2009، العدد 2009 (31 ديسمبر/كانون الأول 2009)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2009-11-22
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Background.
To further improve the screening, diagnosis, and therapy of patients with nonsmall cell lung cancer (NSCLC) additional diagnostic tools are urgently needed.
Gene expression of Cyclooxygenase-2 (COX-2) has been linked to prognosis in patients with NSCLC.
The role of the COX-2 926G>C Single Nucleotide Polymorphism (SNP) in patients with NSCLC remains unclear.
The aim of this study was to investigate the potential of the COX-2 926G>C SNP as a molecular marker in this disease.
Methods.
COX-2 926G>C SNP was analyzed in surgically resected tumor tissue of 85 patients with NSCLC using a PCR-based RFLP technique.
Results.
The COX-2 926G>C SNP genotypes were detected with the following frequencies: GG n=62 (73%), GC n=20 (23%), CC n=3 (4%).
There were no associations between COX-2 SNP genotype and histology, grading or gender detectable.
COX-2 SNP was significantly associated with tumor stage (P=.032) and lymph node status (P=.016, Chi-square test).
With a median followup of 85.9 months, the median survival was 59.7 months.
There were no associations seen between the COX-2 SNP genotype and patients prognosis.
Conclusions.
The COX-2 926G>C SNP is detectable at a high frequency in patients with NSCLC.
The COX-2 926G>C SNP genotype is not a prognostic molecular marker in this disease.
However, patients with the GC or CC genotype seem more susceptible to lymph node metastases and higher tumor stage than patients with the GG genotype.
The results suggest COX-2 926G>C SNP as a molecular marker for lymph node involvement in this disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Grimminger, Peter P.& Stöhlmacher, Jan& Vallböhmer, Daniel& Schneider, Paul Magnus& Hölscher, Arnulf H.& Metzger, Ralf…[et al.]. 2009. Prognostic Significance and Clinicopathological Associations of COX-2 SNP in Patients with Nonsmall Cell Lung Cancer. Journal of Oncology،Vol. 2009, no. 2009, pp.1-5.
https://search.emarefa.net/detail/BIM-448880
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Grimminger, Peter P.…[et al.]. Prognostic Significance and Clinicopathological Associations of COX-2 SNP in Patients with Nonsmall Cell Lung Cancer. Journal of Oncology No. 2009 (2009), pp.1-5.
https://search.emarefa.net/detail/BIM-448880
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Grimminger, Peter P.& Stöhlmacher, Jan& Vallböhmer, Daniel& Schneider, Paul Magnus& Hölscher, Arnulf H.& Metzger, Ralf…[et al.]. Prognostic Significance and Clinicopathological Associations of COX-2 SNP in Patients with Nonsmall Cell Lung Cancer. Journal of Oncology. 2009. Vol. 2009, no. 2009, pp.1-5.
https://search.emarefa.net/detail/BIM-448880
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-448880
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر