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Prognostic Significance and Clinicopathological Associations of COX-2 SNP in Patients with Nonsmall Cell Lung Cancer
Joint Authors
Vallböhmer, Daniel
Brabender, Jan
Grimminger, Peter P.
Schneider, Paul Magnus
Metzger, Ralf
Hölscher, Arnulf H.
Danenberg, Peter V.
Stöhlmacher, Jan
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-11-22
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
To further improve the screening, diagnosis, and therapy of patients with nonsmall cell lung cancer (NSCLC) additional diagnostic tools are urgently needed.
Gene expression of Cyclooxygenase-2 (COX-2) has been linked to prognosis in patients with NSCLC.
The role of the COX-2 926G>C Single Nucleotide Polymorphism (SNP) in patients with NSCLC remains unclear.
The aim of this study was to investigate the potential of the COX-2 926G>C SNP as a molecular marker in this disease.
Methods.
COX-2 926G>C SNP was analyzed in surgically resected tumor tissue of 85 patients with NSCLC using a PCR-based RFLP technique.
Results.
The COX-2 926G>C SNP genotypes were detected with the following frequencies: GG n=62 (73%), GC n=20 (23%), CC n=3 (4%).
There were no associations between COX-2 SNP genotype and histology, grading or gender detectable.
COX-2 SNP was significantly associated with tumor stage (P=.032) and lymph node status (P=.016, Chi-square test).
With a median followup of 85.9 months, the median survival was 59.7 months.
There were no associations seen between the COX-2 SNP genotype and patients prognosis.
Conclusions.
The COX-2 926G>C SNP is detectable at a high frequency in patients with NSCLC.
The COX-2 926G>C SNP genotype is not a prognostic molecular marker in this disease.
However, patients with the GC or CC genotype seem more susceptible to lymph node metastases and higher tumor stage than patients with the GG genotype.
The results suggest COX-2 926G>C SNP as a molecular marker for lymph node involvement in this disease.
American Psychological Association (APA)
Grimminger, Peter P.& Stöhlmacher, Jan& Vallböhmer, Daniel& Schneider, Paul Magnus& Hölscher, Arnulf H.& Metzger, Ralf…[et al.]. 2009. Prognostic Significance and Clinicopathological Associations of COX-2 SNP in Patients with Nonsmall Cell Lung Cancer. Journal of Oncology،Vol. 2009, no. 2009, pp.1-5.
https://search.emarefa.net/detail/BIM-448880
Modern Language Association (MLA)
Grimminger, Peter P.…[et al.]. Prognostic Significance and Clinicopathological Associations of COX-2 SNP in Patients with Nonsmall Cell Lung Cancer. Journal of Oncology No. 2009 (2009), pp.1-5.
https://search.emarefa.net/detail/BIM-448880
American Medical Association (AMA)
Grimminger, Peter P.& Stöhlmacher, Jan& Vallböhmer, Daniel& Schneider, Paul Magnus& Hölscher, Arnulf H.& Metzger, Ralf…[et al.]. Prognostic Significance and Clinicopathological Associations of COX-2 SNP in Patients with Nonsmall Cell Lung Cancer. Journal of Oncology. 2009. Vol. 2009, no. 2009, pp.1-5.
https://search.emarefa.net/detail/BIM-448880
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448880