Efficacy of Goshajinkigan for Oxaliplatin-Induced Peripheral Neuropathy in Colorectal Cancer Patients
المؤلفون المشاركون
Taniwaki, Masafumi
Otsuji, Eigo
Naito, Yuji
Ishikawa, Takeshi
Hosokawa, Toyoshi
Nakanishi, Masayoshi
Kuroboshi, Haruo
Hosoi, Hajime
Yagi, Nobuaki
Miki, Tsuneharu
Kokura, Satoshi
Taguchi, Tetsuya
Nakamura, Terukazu
Yoshida, Naohisa
Kokuba, Yukihito
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-11-07
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Objective.
To evaluate the efficacy of Goshajinkigan for oxaliplatin-induced peripheral neuropathy in colorectal cancer patients.
Patients.
Colorectal cancer patients (N=29) who received ≥4 weeks of Goshajinkigan for oxaliplatin-induced peripheral neuropathy during chemotherapy at Kyoto Prefectural University of Medicine were (Goshajinkigan group) compared to 44 patients who had not received Goshajinkigan during the same period (non-Goshajinkigan group).
Main Outcome Measures.
The effect of Goshajinkigan was graded as curative, effective, stabilizing, or deleterious.
The relationships between the grade of peripheral neuropathy and the dose of oxaliplatin in the Goshajinkigan and non-Goshajinkigan groups were evaluated.
Results.
The effect of Goshajinkigan on peripheral neuropathy in the Goshajinkigan group was curative, effective, stabilizing, and deleterious in 3.4, 20.7, 69.0, and 6.9% of patients, compared to the effect in the non-Goshajinkigan group (4.5, 15.9, 45.5, and 34.1%).
The ratio of deleterious effects was significantly different between these two groups (P=0.04).
A Kaplan-Meier analysis in relation to the cumulative dose of oxaliplatin showed that the incidence of grade 3 peripheral neuropathy tended to be less in the Goshajinkigan group (P=0.05).
There were no significant differences in time to treatment failure and severe adverse events between these two groups.
Conclusions.
Goshajinkigan prevented exacerbation of oxaliplatin-induced peripheral neuropathy.
This trial is registered with UMIN000009956
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yoshida, Naohisa& Hosokawa, Toyoshi& Ishikawa, Takeshi& Yagi, Nobuaki& Kokura, Satoshi& Naito, Yuji…[et al.]. 2013. Efficacy of Goshajinkigan for Oxaliplatin-Induced Peripheral Neuropathy in Colorectal Cancer Patients. Journal of Oncology،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-448892
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yoshida, Naohisa…[et al.]. Efficacy of Goshajinkigan for Oxaliplatin-Induced Peripheral Neuropathy in Colorectal Cancer Patients. Journal of Oncology No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-448892
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yoshida, Naohisa& Hosokawa, Toyoshi& Ishikawa, Takeshi& Yagi, Nobuaki& Kokura, Satoshi& Naito, Yuji…[et al.]. Efficacy of Goshajinkigan for Oxaliplatin-Induced Peripheral Neuropathy in Colorectal Cancer Patients. Journal of Oncology. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-448892
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-448892
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر