Efficacy of Goshajinkigan for Oxaliplatin-Induced Peripheral Neuropathy in Colorectal Cancer Patients
Joint Authors
Taniwaki, Masafumi
Otsuji, Eigo
Naito, Yuji
Ishikawa, Takeshi
Hosokawa, Toyoshi
Nakanishi, Masayoshi
Kuroboshi, Haruo
Hosoi, Hajime
Yagi, Nobuaki
Miki, Tsuneharu
Kokura, Satoshi
Taguchi, Tetsuya
Nakamura, Terukazu
Yoshida, Naohisa
Kokuba, Yukihito
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-07
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
To evaluate the efficacy of Goshajinkigan for oxaliplatin-induced peripheral neuropathy in colorectal cancer patients.
Patients.
Colorectal cancer patients (N=29) who received ≥4 weeks of Goshajinkigan for oxaliplatin-induced peripheral neuropathy during chemotherapy at Kyoto Prefectural University of Medicine were (Goshajinkigan group) compared to 44 patients who had not received Goshajinkigan during the same period (non-Goshajinkigan group).
Main Outcome Measures.
The effect of Goshajinkigan was graded as curative, effective, stabilizing, or deleterious.
The relationships between the grade of peripheral neuropathy and the dose of oxaliplatin in the Goshajinkigan and non-Goshajinkigan groups were evaluated.
Results.
The effect of Goshajinkigan on peripheral neuropathy in the Goshajinkigan group was curative, effective, stabilizing, and deleterious in 3.4, 20.7, 69.0, and 6.9% of patients, compared to the effect in the non-Goshajinkigan group (4.5, 15.9, 45.5, and 34.1%).
The ratio of deleterious effects was significantly different between these two groups (P=0.04).
A Kaplan-Meier analysis in relation to the cumulative dose of oxaliplatin showed that the incidence of grade 3 peripheral neuropathy tended to be less in the Goshajinkigan group (P=0.05).
There were no significant differences in time to treatment failure and severe adverse events between these two groups.
Conclusions.
Goshajinkigan prevented exacerbation of oxaliplatin-induced peripheral neuropathy.
This trial is registered with UMIN000009956
American Psychological Association (APA)
Yoshida, Naohisa& Hosokawa, Toyoshi& Ishikawa, Takeshi& Yagi, Nobuaki& Kokura, Satoshi& Naito, Yuji…[et al.]. 2013. Efficacy of Goshajinkigan for Oxaliplatin-Induced Peripheral Neuropathy in Colorectal Cancer Patients. Journal of Oncology،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-448892
Modern Language Association (MLA)
Yoshida, Naohisa…[et al.]. Efficacy of Goshajinkigan for Oxaliplatin-Induced Peripheral Neuropathy in Colorectal Cancer Patients. Journal of Oncology No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-448892
American Medical Association (AMA)
Yoshida, Naohisa& Hosokawa, Toyoshi& Ishikawa, Takeshi& Yagi, Nobuaki& Kokura, Satoshi& Naito, Yuji…[et al.]. Efficacy of Goshajinkigan for Oxaliplatin-Induced Peripheral Neuropathy in Colorectal Cancer Patients. Journal of Oncology. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-448892
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448892