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Gab Docking Proteins in Cardiovascular Disease, Cancer, and Inflammation
المؤلفون المشاركون
Komuro, Issei
Nakaoka, Yoshikazu
المصدر
International Journal of Inflammation
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-01-22
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
The docking proteins of the Grb2-associated binder (Gab) family have emerged as crucial signaling compartments in metazoans.
In mammals, the Gab proteins, consisting of Gab1, Gab2, and Gab3, are involved in the amplification and integration of signal transduction evoked by a variety of extracellular stimuli, including growth factors, cytokines, antigens, and other molecules.
Gab proteins lack the enzymatic activity themselves; however, when phosphorylated on tyrosine residues, they provide binding sites for multiple Src homology-2 (SH2) domain-containing proteins, such as SH2-containing protein tyrosine phosphatase 2 (SHP2), phosphatidylinositol 3-kinase regulatory subunit p85, phospholipase Cγ, Crk, and GC-GAP.
Through these interactions, the Gab proteins transduce signals from activated receptors into pathways with distinct biological functions, thereby contributing to signal diversification.
They are known to play crucial roles in numerous physiological processes through their associations with SHP2 and p85.
In addition, abnormal Gab protein signaling has been linked to human diseases including cancer, cardiovascular disease, and inflammatory disorders.
In this paper, we provide an overview of the structure, effector functions, and regulation of the Gab docking proteins, with a special focus on their associations with cardiovascular disease, cancer, and inflammation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nakaoka, Yoshikazu& Komuro, Issei. 2013. Gab Docking Proteins in Cardiovascular Disease, Cancer, and Inflammation. International Journal of Inflammation،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-449006
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nakaoka, Yoshikazu& Komuro, Issei. Gab Docking Proteins in Cardiovascular Disease, Cancer, and Inflammation. International Journal of Inflammation No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-449006
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nakaoka, Yoshikazu& Komuro, Issei. Gab Docking Proteins in Cardiovascular Disease, Cancer, and Inflammation. International Journal of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-449006
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-449006
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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