Gab Docking Proteins in Cardiovascular Disease, Cancer, and Inflammation
Joint Authors
Komuro, Issei
Nakaoka, Yoshikazu
Source
International Journal of Inflammation
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-22
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The docking proteins of the Grb2-associated binder (Gab) family have emerged as crucial signaling compartments in metazoans.
In mammals, the Gab proteins, consisting of Gab1, Gab2, and Gab3, are involved in the amplification and integration of signal transduction evoked by a variety of extracellular stimuli, including growth factors, cytokines, antigens, and other molecules.
Gab proteins lack the enzymatic activity themselves; however, when phosphorylated on tyrosine residues, they provide binding sites for multiple Src homology-2 (SH2) domain-containing proteins, such as SH2-containing protein tyrosine phosphatase 2 (SHP2), phosphatidylinositol 3-kinase regulatory subunit p85, phospholipase Cγ, Crk, and GC-GAP.
Through these interactions, the Gab proteins transduce signals from activated receptors into pathways with distinct biological functions, thereby contributing to signal diversification.
They are known to play crucial roles in numerous physiological processes through their associations with SHP2 and p85.
In addition, abnormal Gab protein signaling has been linked to human diseases including cancer, cardiovascular disease, and inflammatory disorders.
In this paper, we provide an overview of the structure, effector functions, and regulation of the Gab docking proteins, with a special focus on their associations with cardiovascular disease, cancer, and inflammation.
American Psychological Association (APA)
Nakaoka, Yoshikazu& Komuro, Issei. 2013. Gab Docking Proteins in Cardiovascular Disease, Cancer, and Inflammation. International Journal of Inflammation،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-449006
Modern Language Association (MLA)
Nakaoka, Yoshikazu& Komuro, Issei. Gab Docking Proteins in Cardiovascular Disease, Cancer, and Inflammation. International Journal of Inflammation No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-449006
American Medical Association (AMA)
Nakaoka, Yoshikazu& Komuro, Issei. Gab Docking Proteins in Cardiovascular Disease, Cancer, and Inflammation. International Journal of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-449006
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-449006