A Longitudinal Study of the Effect of Genistein on Bone in Two Different Murine Models of Diminished Estrogen-Producing Capacity
المؤلفون المشاركون
Hoyer, Patricia B.
Weaver, Connie M.
Reinwald, Susan
Turner, Charles H.
Barnes, Stephen
Mayer, Loretta P.
المصدر
العدد
المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2009-10-18
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
This experiment was designed to assess the capacity of dietary genistein (GEN), to attenuate bone loss in ovariectomized (OVX) and ovary-intact VCD-treated mice.
Pretreatment of mice with 4-vinylcyclohexene diepoxide (VCD) gradually and selectively destroys ovarian follicles whilst leaving ovarian androgen-producing cells largely intact.
VCD induces a perimenopause-like condition prior to the onset of reproductive acyclicity.
Sixteen-week-old C57BL/6J mice were randomized to five treatment groups: sham(SHM), OVX, SHM + VCD, OVX + GEN, and SHM + VCD + GEN.
In vivo, blood samples were drawn for hormone and isoflavone analyses, estrous cycles were monitored, and X-ray imaging was performed to assess changes in bone parameters.
Following sacrifice, ovaries were assessed histologically, bone microarchitecture was evaluated via microcomputed tomography, and bone mechanical properties were measured.
Some effects of GEN were observed in OVX mice, but GEN effects were not able to be evaluated in VCD-treated mice due to the subtle diminution of bone during the 4 months of this experiment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Reinwald, Susan& Mayer, Loretta P.& Hoyer, Patricia B.& Turner, Charles H.& Barnes, Stephen& Weaver, Connie M.. 2009. A Longitudinal Study of the Effect of Genistein on Bone in Two Different Murine Models of Diminished Estrogen-Producing Capacity. Journal of Osteoporosis،Vol. 2010, no. 2010, pp.1-14.
https://search.emarefa.net/detail/BIM-449283
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Reinwald, Susan…[et al.]. A Longitudinal Study of the Effect of Genistein on Bone in Two Different Murine Models of Diminished Estrogen-Producing Capacity. Journal of Osteoporosis No. 2010 (2010), pp.1-14.
https://search.emarefa.net/detail/BIM-449283
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Reinwald, Susan& Mayer, Loretta P.& Hoyer, Patricia B.& Turner, Charles H.& Barnes, Stephen& Weaver, Connie M.. A Longitudinal Study of the Effect of Genistein on Bone in Two Different Murine Models of Diminished Estrogen-Producing Capacity. Journal of Osteoporosis. 2009. Vol. 2010, no. 2010, pp.1-14.
https://search.emarefa.net/detail/BIM-449283
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-449283
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر