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A Longitudinal Study of the Effect of Genistein on Bone in Two Different Murine Models of Diminished Estrogen-Producing Capacity
Joint Authors
Hoyer, Patricia B.
Weaver, Connie M.
Reinwald, Susan
Turner, Charles H.
Barnes, Stephen
Mayer, Loretta P.
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-10-18
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
This experiment was designed to assess the capacity of dietary genistein (GEN), to attenuate bone loss in ovariectomized (OVX) and ovary-intact VCD-treated mice.
Pretreatment of mice with 4-vinylcyclohexene diepoxide (VCD) gradually and selectively destroys ovarian follicles whilst leaving ovarian androgen-producing cells largely intact.
VCD induces a perimenopause-like condition prior to the onset of reproductive acyclicity.
Sixteen-week-old C57BL/6J mice were randomized to five treatment groups: sham(SHM), OVX, SHM + VCD, OVX + GEN, and SHM + VCD + GEN.
In vivo, blood samples were drawn for hormone and isoflavone analyses, estrous cycles were monitored, and X-ray imaging was performed to assess changes in bone parameters.
Following sacrifice, ovaries were assessed histologically, bone microarchitecture was evaluated via microcomputed tomography, and bone mechanical properties were measured.
Some effects of GEN were observed in OVX mice, but GEN effects were not able to be evaluated in VCD-treated mice due to the subtle diminution of bone during the 4 months of this experiment.
American Psychological Association (APA)
Reinwald, Susan& Mayer, Loretta P.& Hoyer, Patricia B.& Turner, Charles H.& Barnes, Stephen& Weaver, Connie M.. 2009. A Longitudinal Study of the Effect of Genistein on Bone in Two Different Murine Models of Diminished Estrogen-Producing Capacity. Journal of Osteoporosis،Vol. 2010, no. 2010, pp.1-14.
https://search.emarefa.net/detail/BIM-449283
Modern Language Association (MLA)
Reinwald, Susan…[et al.]. A Longitudinal Study of the Effect of Genistein on Bone in Two Different Murine Models of Diminished Estrogen-Producing Capacity. Journal of Osteoporosis No. 2010 (2010), pp.1-14.
https://search.emarefa.net/detail/BIM-449283
American Medical Association (AMA)
Reinwald, Susan& Mayer, Loretta P.& Hoyer, Patricia B.& Turner, Charles H.& Barnes, Stephen& Weaver, Connie M.. A Longitudinal Study of the Effect of Genistein on Bone in Two Different Murine Models of Diminished Estrogen-Producing Capacity. Journal of Osteoporosis. 2009. Vol. 2010, no. 2010, pp.1-14.
https://search.emarefa.net/detail/BIM-449283
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-449283