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Attenuation of Proinflammatory Responses by S-[6]-Gingerol via Inhibition of ROSNF-Kappa BCOX2 Activation in HuH7 Cells
المؤلفون المشاركون
Heather, Alison K.
Duke, Colin C.
McGrath, Kristine C. Y.
Roufogalis, Basil D.
Li, Xiao-Hong
Tran, Van H.
Li, Yi-Ming
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-06-16
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Introduction.
Hepatic inflammation underlies the pathogenesis of chronic diseases such as insulin resistance and type 2 diabetes mellitus.
S-[6]-Gingerol has been shown to have anti-inflammatory properties.
Important inflammatory mediators of interleukins include nuclear factor κB (NFκB) and cyclooxygenase 2 (COX2).
We now explore the mechanism of anti-inflammatory effects of S-[6]-gingerol in liver cells.
Methods.
HuH7 cells were stimulated with IL1β to establish an in vitro hepatic inflammatory model.
Results.
S-[6]-Gingerol attenuated IL1β-induced inflammation and oxidative stress in HuH7 cells, as evidenced by decreasing mRNA levels of inflammatory factor IL6, IL8, and SAA1, suppression of ROS generation, and increasing mRNA levels of DHCR24.
In addition, S-[6]-gingerol reduced IL1β-induced COX2 upregulation as well as NFκB activity.
Similar to the protective effects of S-[6]-gingerol, both NS-398 (a selective COX2 inhibitor) and PDTC (a selective NFκB inhibitor) suppressed mRNA levels of IL6, IL8, and SAA1.
Importantly, PDTC attenuated IL1β-induced overexpression of COX2.
Of particular note, the protective effect of S-[6]-gingerol against the IL1β-induced inflammatory response was similar to that of BHT, an ROS scavenger.
Conclusions.
The findings of this study demonstrate that S-[6]-gingerol protects HuH7 cells against IL1β-induced inflammatory insults through inhibition of the ROS/NFκB/COX2 pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Xiao-Hong& McGrath, Kristine C. Y.& Tran, Van H.& Li, Yi-Ming& Duke, Colin C.& Roufogalis, Basil D.…[et al.]. 2013. Attenuation of Proinflammatory Responses by S-[6]-Gingerol via Inhibition of ROSNF-Kappa BCOX2 Activation in HuH7 Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-449380
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Xiao-Hong…[et al.]. Attenuation of Proinflammatory Responses by S-[6]-Gingerol via Inhibition of ROSNF-Kappa BCOX2 Activation in HuH7 Cells. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-449380
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Xiao-Hong& McGrath, Kristine C. Y.& Tran, Van H.& Li, Yi-Ming& Duke, Colin C.& Roufogalis, Basil D.…[et al.]. Attenuation of Proinflammatory Responses by S-[6]-Gingerol via Inhibition of ROSNF-Kappa BCOX2 Activation in HuH7 Cells. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-449380
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-449380
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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