![](/images/graphics-bg.png)
Attenuation of Proinflammatory Responses by S-[6]-Gingerol via Inhibition of ROSNF-Kappa BCOX2 Activation in HuH7 Cells
Joint Authors
Heather, Alison K.
Duke, Colin C.
McGrath, Kristine C. Y.
Roufogalis, Basil D.
Li, Xiao-Hong
Tran, Van H.
Li, Yi-Ming
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-16
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Introduction.
Hepatic inflammation underlies the pathogenesis of chronic diseases such as insulin resistance and type 2 diabetes mellitus.
S-[6]-Gingerol has been shown to have anti-inflammatory properties.
Important inflammatory mediators of interleukins include nuclear factor κB (NFκB) and cyclooxygenase 2 (COX2).
We now explore the mechanism of anti-inflammatory effects of S-[6]-gingerol in liver cells.
Methods.
HuH7 cells were stimulated with IL1β to establish an in vitro hepatic inflammatory model.
Results.
S-[6]-Gingerol attenuated IL1β-induced inflammation and oxidative stress in HuH7 cells, as evidenced by decreasing mRNA levels of inflammatory factor IL6, IL8, and SAA1, suppression of ROS generation, and increasing mRNA levels of DHCR24.
In addition, S-[6]-gingerol reduced IL1β-induced COX2 upregulation as well as NFκB activity.
Similar to the protective effects of S-[6]-gingerol, both NS-398 (a selective COX2 inhibitor) and PDTC (a selective NFκB inhibitor) suppressed mRNA levels of IL6, IL8, and SAA1.
Importantly, PDTC attenuated IL1β-induced overexpression of COX2.
Of particular note, the protective effect of S-[6]-gingerol against the IL1β-induced inflammatory response was similar to that of BHT, an ROS scavenger.
Conclusions.
The findings of this study demonstrate that S-[6]-gingerol protects HuH7 cells against IL1β-induced inflammatory insults through inhibition of the ROS/NFκB/COX2 pathway.
American Psychological Association (APA)
Li, Xiao-Hong& McGrath, Kristine C. Y.& Tran, Van H.& Li, Yi-Ming& Duke, Colin C.& Roufogalis, Basil D.…[et al.]. 2013. Attenuation of Proinflammatory Responses by S-[6]-Gingerol via Inhibition of ROSNF-Kappa BCOX2 Activation in HuH7 Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-449380
Modern Language Association (MLA)
Li, Xiao-Hong…[et al.]. Attenuation of Proinflammatory Responses by S-[6]-Gingerol via Inhibition of ROSNF-Kappa BCOX2 Activation in HuH7 Cells. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-449380
American Medical Association (AMA)
Li, Xiao-Hong& McGrath, Kristine C. Y.& Tran, Van H.& Li, Yi-Ming& Duke, Colin C.& Roufogalis, Basil D.…[et al.]. Attenuation of Proinflammatory Responses by S-[6]-Gingerol via Inhibition of ROSNF-Kappa BCOX2 Activation in HuH7 Cells. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-449380
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-449380