Involvement of Potassium Channels in Vasorelaxant Effect Induced by Valeriana prionophylla Standl. in Rat Mesenteric Artery
المؤلفون المشاركون
Rodrigues, Lilia Simone Urzedo
Oliveira Filho, Abrahão Alves de
de Albuquerque, Jamile Morais
Araújo, Jaíse Paiva
Maciel, Priscilla Maria Pereira
Cáceres, Armando
de Medeiros, Isac Almeida
Cechinel Filho, Valdir
Silva, Darizy Flávia
Reis, Milena Ramos
Fregoneze, Josmara Bartolomei
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-08-14
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Assays in vitro and in vivo were performed on extract from roots and leaves from the Valeriana prionophylla Standl.
(VPR and VPF, resp.).
In phenylephrine (1 μM) precontracted rings, VPR (0.01–300 μg/mL) induced a concentration-dependent relaxation (maximum response (MR) = 75.4 ± 4.0%, EC50 = 5.97 (3.8–9.3) μg/mL, n=6]); this effect was significantly modified after removal of the endothelium (EC50 = 39.6 (27.2–57.6) μg/mL, P<0.05).
However, VPF-induced vasorelaxation was less effective compared to VPR.
When rings were preincubated with L-NAME (100 μM) or indomethacin (10 μM), the endothelium-dependent relaxation induced by VPR was significantly attenuated (MR = 20.9 ± 2.3%, 34.2 ± 2.9%, resp., P<0.001).
In rings denuded endothelium, precontracted with KCl (80 mM), or in preparations pretreated with KCl (20 mM) or tetraethylammonium (1 or 3 mM), the vasorelaxant activity of VPR was significantly attenuated (MR = 40.0 ± 8.2, n=5; 50.5 ± 6.0%; 49.3 ± 6.4%; 46.8 ± 6.2%; resp., P<0.01).
In contrast, neither glibenclamide (10 μM), barium chloride (30 μM), nor 4-aminopyridine (1 mM) affected VPR-induced relaxation.
Taken together, these results demonstrate that hypotension induced by VPR seems to involve, at least in part, a vascular component.
Furthermore, endothelium-independent relaxation induced by VPR involves K+ channels activation, most likely due to BKCa channels, in the rat superior mesenteric artery.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Reis, Milena Ramos& Oliveira Filho, Abrahão Alves de& Rodrigues, Lilia Simone Urzedo& Araújo, Jaíse Paiva& Maciel, Priscilla Maria Pereira& de Albuquerque, Jamile Morais…[et al.]. 2013. Involvement of Potassium Channels in Vasorelaxant Effect Induced by Valeriana prionophylla Standl. in Rat Mesenteric Artery. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-449534
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Reis, Milena Ramos…[et al.]. Involvement of Potassium Channels in Vasorelaxant Effect Induced by Valeriana prionophylla Standl. in Rat Mesenteric Artery. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-449534
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Reis, Milena Ramos& Oliveira Filho, Abrahão Alves de& Rodrigues, Lilia Simone Urzedo& Araújo, Jaíse Paiva& Maciel, Priscilla Maria Pereira& de Albuquerque, Jamile Morais…[et al.]. Involvement of Potassium Channels in Vasorelaxant Effect Induced by Valeriana prionophylla Standl. in Rat Mesenteric Artery. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-449534
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-449534
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر