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Involvement of Potassium Channels in Vasorelaxant Effect Induced by Valeriana prionophylla Standl. in Rat Mesenteric Artery
Joint Authors
Rodrigues, Lilia Simone Urzedo
Oliveira Filho, Abrahão Alves de
de Albuquerque, Jamile Morais
Araújo, Jaíse Paiva
Maciel, Priscilla Maria Pereira
Cáceres, Armando
de Medeiros, Isac Almeida
Cechinel Filho, Valdir
Silva, Darizy Flávia
Reis, Milena Ramos
Fregoneze, Josmara Bartolomei
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-14
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Assays in vitro and in vivo were performed on extract from roots and leaves from the Valeriana prionophylla Standl.
(VPR and VPF, resp.).
In phenylephrine (1 μM) precontracted rings, VPR (0.01–300 μg/mL) induced a concentration-dependent relaxation (maximum response (MR) = 75.4 ± 4.0%, EC50 = 5.97 (3.8–9.3) μg/mL, n=6]); this effect was significantly modified after removal of the endothelium (EC50 = 39.6 (27.2–57.6) μg/mL, P<0.05).
However, VPF-induced vasorelaxation was less effective compared to VPR.
When rings were preincubated with L-NAME (100 μM) or indomethacin (10 μM), the endothelium-dependent relaxation induced by VPR was significantly attenuated (MR = 20.9 ± 2.3%, 34.2 ± 2.9%, resp., P<0.001).
In rings denuded endothelium, precontracted with KCl (80 mM), or in preparations pretreated with KCl (20 mM) or tetraethylammonium (1 or 3 mM), the vasorelaxant activity of VPR was significantly attenuated (MR = 40.0 ± 8.2, n=5; 50.5 ± 6.0%; 49.3 ± 6.4%; 46.8 ± 6.2%; resp., P<0.01).
In contrast, neither glibenclamide (10 μM), barium chloride (30 μM), nor 4-aminopyridine (1 mM) affected VPR-induced relaxation.
Taken together, these results demonstrate that hypotension induced by VPR seems to involve, at least in part, a vascular component.
Furthermore, endothelium-independent relaxation induced by VPR involves K+ channels activation, most likely due to BKCa channels, in the rat superior mesenteric artery.
American Psychological Association (APA)
Reis, Milena Ramos& Oliveira Filho, Abrahão Alves de& Rodrigues, Lilia Simone Urzedo& Araújo, Jaíse Paiva& Maciel, Priscilla Maria Pereira& de Albuquerque, Jamile Morais…[et al.]. 2013. Involvement of Potassium Channels in Vasorelaxant Effect Induced by Valeriana prionophylla Standl. in Rat Mesenteric Artery. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-449534
Modern Language Association (MLA)
Reis, Milena Ramos…[et al.]. Involvement of Potassium Channels in Vasorelaxant Effect Induced by Valeriana prionophylla Standl. in Rat Mesenteric Artery. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-449534
American Medical Association (AMA)
Reis, Milena Ramos& Oliveira Filho, Abrahão Alves de& Rodrigues, Lilia Simone Urzedo& Araújo, Jaíse Paiva& Maciel, Priscilla Maria Pereira& de Albuquerque, Jamile Morais…[et al.]. Involvement of Potassium Channels in Vasorelaxant Effect Induced by Valeriana prionophylla Standl. in Rat Mesenteric Artery. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-449534
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-449534