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Commercial Bovine Proteoglycan Is Highly Arthritogenic and Can Be Used as an Alternative Antigen Source for PGIA Model
المؤلفون المشاركون
Balbino, Bianca
Chiuso-Minicucci, Fernanda
Ishikawa, Larissa Lumi Watanabe
Colavite, Priscila Maria
Zorzella-Pezavento, Sofia Fernanda Gonçalves
França, Thais Graziela Donegá
Sartori, Alexandrina
da Rosa, Larissa Camargo
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-27
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Rheumatoid arthritis (RA) is the most common systemic autoimmune disease.
It affects mainly the joints, causing synovitis, cartilage destruction, and bone erosion.
Many experimental models are used to study the mechanisms involved in immunopathogenesis and new therapies for this disease.
Proteoglycan-induced arthritis (PGIA) is a widely used model based on the cross-reactivity of injected foreign (usually human) PG and mice self-PG.
Considering the complexity of the extraction and purification of human PG, in this study we evaluated the arthritogenicity of bovine PG that is commercially available.
Bovine PG was highly arthritogenic, triggering 100% incidence of arthritis in female BALB/c retired breeder mice.
Animals immunized with bovine PG presented clinical symptoms and histopathological features similar to human RA and other experimental models.
Moreover, bovine PG immunization determined higher levels of proinflammatory and anti-inflammatory cytokines in arthritic mice compared to healthy ones.
As expected, only the arthritic group produced IgG1 and IgG2a antibodies against PG.
Thus, commercial bovine PG can be used as an alternative antigenic source to PGIA for the study of many RA aspects, including the immunopathogenesis of the disease and also the development of new therapies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ishikawa, Larissa Lumi Watanabe& Colavite, Priscila Maria& da Rosa, Larissa Camargo& Balbino, Bianca& França, Thais Graziela Donegá& Zorzella-Pezavento, Sofia Fernanda Gonçalves…[et al.]. 2014. Commercial Bovine Proteoglycan Is Highly Arthritogenic and Can Be Used as an Alternative Antigen Source for PGIA Model. BioMed Research International،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-449632
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ishikawa, Larissa Lumi Watanabe…[et al.]. Commercial Bovine Proteoglycan Is Highly Arthritogenic and Can Be Used as an Alternative Antigen Source for PGIA Model. BioMed Research International No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-449632
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ishikawa, Larissa Lumi Watanabe& Colavite, Priscila Maria& da Rosa, Larissa Camargo& Balbino, Bianca& França, Thais Graziela Donegá& Zorzella-Pezavento, Sofia Fernanda Gonçalves…[et al.]. Commercial Bovine Proteoglycan Is Highly Arthritogenic and Can Be Used as an Alternative Antigen Source for PGIA Model. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-449632
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-449632
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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