The SSX Family of Cancer-Testis Antigens as Target Proteins for Tumor Therapy
المؤلفون المشاركون
McNeel, Douglas G.
Smith, Heath A.
المصدر
Clinical and Developmental Immunology
العدد
المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-18، 18ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-10-11
دولة النشر
مصر
عدد الصفحات
18
التخصصات الرئيسية
الملخص EN
Cancer-testis antigens (CTAs) represent an expanding class of tumor-associated proteins defined on the basis of their tissue-restricted expression to testis or ovary germline cells and frequent ectopic expression in tumor tissue.
The expression of CTA in MHC class I-deficient germline cells makes these proteins particularly attractive as immunotherapeutic targets because they serve as essentially tumor-specific antigens for MHC class I-restricted CD8+ T cells.
Moreover, because CTAs are expressed in many types of cancer, any therapeutic developed to target these antigens might have efficacy for multiple cancer types.
Of particular interest among CTAs is the synovial sarcoma X chromosome breakpoint (SSX) family of proteins, which includes ten highly homologous family members.
Expression of SSX proteins in tumor tissues has been associated with advanced stages of disease and worse patient prognosis.
Additionally, both humoral and cell-mediated immune responses to SSX proteins have been demonstrated in patients with tumors of varying histological origin, which indicates that natural immune responses can be spontaneously generated to these antigens in cancer patients.
The current review will describe the history and identification of this family of proteins, as well as what is known of their function, expression in normal and malignant tissues, and immunogenicity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Smith, Heath A.& McNeel, Douglas G.. 2010. The SSX Family of Cancer-Testis Antigens as Target Proteins for Tumor Therapy. Clinical and Developmental Immunology،Vol. 2010, no. 2010, pp.1-18.
https://search.emarefa.net/detail/BIM-449798
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Smith, Heath A.& McNeel, Douglas G.. The SSX Family of Cancer-Testis Antigens as Target Proteins for Tumor Therapy. Clinical and Developmental Immunology No. 2010 (2010), pp.1-18.
https://search.emarefa.net/detail/BIM-449798
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Smith, Heath A.& McNeel, Douglas G.. The SSX Family of Cancer-Testis Antigens as Target Proteins for Tumor Therapy. Clinical and Developmental Immunology. 2010. Vol. 2010, no. 2010, pp.1-18.
https://search.emarefa.net/detail/BIM-449798
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-449798
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر