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The SSX Family of Cancer-Testis Antigens as Target Proteins for Tumor Therapy
Joint Authors
McNeel, Douglas G.
Smith, Heath A.
Source
Clinical and Developmental Immunology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-10-11
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Cancer-testis antigens (CTAs) represent an expanding class of tumor-associated proteins defined on the basis of their tissue-restricted expression to testis or ovary germline cells and frequent ectopic expression in tumor tissue.
The expression of CTA in MHC class I-deficient germline cells makes these proteins particularly attractive as immunotherapeutic targets because they serve as essentially tumor-specific antigens for MHC class I-restricted CD8+ T cells.
Moreover, because CTAs are expressed in many types of cancer, any therapeutic developed to target these antigens might have efficacy for multiple cancer types.
Of particular interest among CTAs is the synovial sarcoma X chromosome breakpoint (SSX) family of proteins, which includes ten highly homologous family members.
Expression of SSX proteins in tumor tissues has been associated with advanced stages of disease and worse patient prognosis.
Additionally, both humoral and cell-mediated immune responses to SSX proteins have been demonstrated in patients with tumors of varying histological origin, which indicates that natural immune responses can be spontaneously generated to these antigens in cancer patients.
The current review will describe the history and identification of this family of proteins, as well as what is known of their function, expression in normal and malignant tissues, and immunogenicity.
American Psychological Association (APA)
Smith, Heath A.& McNeel, Douglas G.. 2010. The SSX Family of Cancer-Testis Antigens as Target Proteins for Tumor Therapy. Clinical and Developmental Immunology،Vol. 2010, no. 2010, pp.1-18.
https://search.emarefa.net/detail/BIM-449798
Modern Language Association (MLA)
Smith, Heath A.& McNeel, Douglas G.. The SSX Family of Cancer-Testis Antigens as Target Proteins for Tumor Therapy. Clinical and Developmental Immunology No. 2010 (2010), pp.1-18.
https://search.emarefa.net/detail/BIM-449798
American Medical Association (AMA)
Smith, Heath A.& McNeel, Douglas G.. The SSX Family of Cancer-Testis Antigens as Target Proteins for Tumor Therapy. Clinical and Developmental Immunology. 2010. Vol. 2010, no. 2010, pp.1-18.
https://search.emarefa.net/detail/BIM-449798
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-449798