Association of Single Nucleotide Polymorphisms in Estrogen Receptor Alpha Gene with Susceptibility to Knee Osteoarthritis : A Case-Control Study in a Chinese Han Population
المؤلفون المشاركون
Shi, Dongquan
Teng, Huajian
Wang, Chao
Jiang, Qing
Dai, Xiaoyu
Xu, Zhihong
Chen, Dongyang
Dai, Jin
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-03-17
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Osteoarthritis (OA) is the most prevalent form of arthritis and its multifactorial nature has been increasingly recognized.
Genetic factors play an important role in OA etiology and estrogen receptor alpha (ESR1) gene polymorphisms may be involved.
This study tried to explore whether the ESR1 gene single nucleotide polymorphisms (SNPs) were associated with primary knee OA in the Chinese Han population.
Two SNPs, rs2234693 and rs9340799, were genotyped in 469 cases and 522 controls.
Rs2234693 was associated with knee OA in the dominant genetic model (TT + TC versus CC) (P=0.025) and a higher T allele frequency existed (P=0.047) among females.
The combined genotype (TT + TC) (P=0.025) and T allele (P=0.016) were related with mild knee OA only.
For rs9340799, A allele was associated with knee OA in all subjects (P=0.031) and females (P=0.046).
Statistical differences were detected in the dominant genetic model (AA + AG versus GG) among females (P=0.030).
The combined genotype (AA + AG) (P=0.036) and A allele (P=0.039) were merely correlated with mild knee OA.
ESR1 gene is considerably associated with knee OA etiology in the Chinese Han population.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dai, Xiaoyu& Wang, Chao& Dai, Jin& Shi, Dongquan& Xu, Zhihong& Chen, Dongyang…[et al.]. 2014. Association of Single Nucleotide Polymorphisms in Estrogen Receptor Alpha Gene with Susceptibility to Knee Osteoarthritis : A Case-Control Study in a Chinese Han Population. BioMed Research International،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-449881
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dai, Xiaoyu…[et al.]. Association of Single Nucleotide Polymorphisms in Estrogen Receptor Alpha Gene with Susceptibility to Knee Osteoarthritis : A Case-Control Study in a Chinese Han Population. BioMed Research International No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-449881
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dai, Xiaoyu& Wang, Chao& Dai, Jin& Shi, Dongquan& Xu, Zhihong& Chen, Dongyang…[et al.]. Association of Single Nucleotide Polymorphisms in Estrogen Receptor Alpha Gene with Susceptibility to Knee Osteoarthritis : A Case-Control Study in a Chinese Han Population. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-449881
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-449881
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر