Association of Single Nucleotide Polymorphisms in Estrogen Receptor Alpha Gene with Susceptibility to Knee Osteoarthritis : A Case-Control Study in a Chinese Han Population
Joint Authors
Shi, Dongquan
Teng, Huajian
Wang, Chao
Jiang, Qing
Dai, Xiaoyu
Xu, Zhihong
Chen, Dongyang
Dai, Jin
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-17
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Osteoarthritis (OA) is the most prevalent form of arthritis and its multifactorial nature has been increasingly recognized.
Genetic factors play an important role in OA etiology and estrogen receptor alpha (ESR1) gene polymorphisms may be involved.
This study tried to explore whether the ESR1 gene single nucleotide polymorphisms (SNPs) were associated with primary knee OA in the Chinese Han population.
Two SNPs, rs2234693 and rs9340799, were genotyped in 469 cases and 522 controls.
Rs2234693 was associated with knee OA in the dominant genetic model (TT + TC versus CC) (P=0.025) and a higher T allele frequency existed (P=0.047) among females.
The combined genotype (TT + TC) (P=0.025) and T allele (P=0.016) were related with mild knee OA only.
For rs9340799, A allele was associated with knee OA in all subjects (P=0.031) and females (P=0.046).
Statistical differences were detected in the dominant genetic model (AA + AG versus GG) among females (P=0.030).
The combined genotype (AA + AG) (P=0.036) and A allele (P=0.039) were merely correlated with mild knee OA.
ESR1 gene is considerably associated with knee OA etiology in the Chinese Han population.
American Psychological Association (APA)
Dai, Xiaoyu& Wang, Chao& Dai, Jin& Shi, Dongquan& Xu, Zhihong& Chen, Dongyang…[et al.]. 2014. Association of Single Nucleotide Polymorphisms in Estrogen Receptor Alpha Gene with Susceptibility to Knee Osteoarthritis : A Case-Control Study in a Chinese Han Population. BioMed Research International،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-449881
Modern Language Association (MLA)
Dai, Xiaoyu…[et al.]. Association of Single Nucleotide Polymorphisms in Estrogen Receptor Alpha Gene with Susceptibility to Knee Osteoarthritis : A Case-Control Study in a Chinese Han Population. BioMed Research International No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-449881
American Medical Association (AMA)
Dai, Xiaoyu& Wang, Chao& Dai, Jin& Shi, Dongquan& Xu, Zhihong& Chen, Dongyang…[et al.]. Association of Single Nucleotide Polymorphisms in Estrogen Receptor Alpha Gene with Susceptibility to Knee Osteoarthritis : A Case-Control Study in a Chinese Han Population. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-449881
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-449881