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Breast Carcinoma Progression and Tumour Vascular Markers Related to Apoptotic Mechanisms
المؤلفون المشاركون
Urban, Peter
Bilecova-Rabajdova, Miroslava
Kruzliak, Peter
Fialkovicová, Viera
Marekova, Maria
Gregova, Kristina
Varga, Jan
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-02-18
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
In the last few years, the cancer research had tried to identify and characterize new biochemical and molecular pathways in which the inhibition induces prosurvival mechanisms.
Our work describes the expression of two different members of apoptotic regulatory pathway and their relationship with a progression of breast carcinoma.
Materials and Methods.
We compared expression of genes related to apoptosis (DR6 and Gpm6B) in the blood of patients suffering from stage I of breast cancer in different grades (I–IV), with healthy controls.
After isolation of mRNA, transcription of mRNA into the cDNA was performed.
The quantification of gene expression changes in DR6 and Gpm6B was detected by RT-PCR method.
Analysis at the protein level was performed by the Western blot.Results.
In statistical analysis of Dr6 mRNA level changes we detected significant increase starting in Grading 1 (G1) and reached maximal level in G3.This expression on mRNA levels was similar to protein levels, which copy rising tendency with maximal value in G3.
The results of Gpm6B were significantly lower.Conclusion.
This result showed that antiapoptotic signalling during neovascularization is increased significantly.
It would be advisable in the future to study the influence of cytostatic treatment on the expression of genes related to apoptotic pathways and their relationship with progression of breast cancer tumours.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bilecova-Rabajdova, Miroslava& Urban, Peter& Gregova, Kristina& Varga, Jan& Fialkovicová, Viera& Kruzliak, Peter…[et al.]. 2014. Breast Carcinoma Progression and Tumour Vascular Markers Related to Apoptotic Mechanisms. Disease Markers،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-450227
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bilecova-Rabajdova, Miroslava…[et al.]. Breast Carcinoma Progression and Tumour Vascular Markers Related to Apoptotic Mechanisms. Disease Markers No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-450227
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bilecova-Rabajdova, Miroslava& Urban, Peter& Gregova, Kristina& Varga, Jan& Fialkovicová, Viera& Kruzliak, Peter…[et al.]. Breast Carcinoma Progression and Tumour Vascular Markers Related to Apoptotic Mechanisms. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-450227
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-450227
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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