Endothelium-Derived Hyperpolarizing Factor and Vascular Function
المؤلفون المشاركون
Ozkor, Muhiddin A.
Quyyumi, Arshed A.
المصدر
Cardiology Research and Practice
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-08-15
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Endothelial function refers to a multitude of physiological processes that maintain healthy homeostasis of the vascular wall.
Exposure of the endothelium to cardiac risk factors results in endothelial dysfunction and is associated with an alteration in the balance of vasoactive substances produced by endothelial cells.
These include a reduction in nitric oxide (NO), an increase in generation of potential vasoconstrictor substances and a potential compensatory increase in other mediators of vasodilation.
The latter has been surmised from data demonstrating persistent endothelium-dependent vasodilatation despite complete inhibition of NO and prostaglandins.
This remaining non-NO, non-prostaglandin mediated endothelium-dependent vasodilator response has been attributed to endothelium-derived hyperpolarizing factor/s (EDHF).
Endothelial hyperpolarization is likely due to several factors that appear to be site and species specific.
Experimental studies suggest that the contribution of the EDHFs increase as the vessel size decreases, with a predominance of EDHF activity in the resistance vessels, and a compensatory up-regulation of hyperpolarization in states characterized by reduced NO availability.
Since endothelial dysfunction is a precursor for atherosclerosis development and its magnitude is a reflection of future risk, then the mechanisms underlying endothelial dysfunction need to be fully understood, so that adequate therapeutic interventions can be designed.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ozkor, Muhiddin A.& Quyyumi, Arshed A.. 2011. Endothelium-Derived Hyperpolarizing Factor and Vascular Function. Cardiology Research and Practice،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-450242
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ozkor, Muhiddin A.& Quyyumi, Arshed A.. Endothelium-Derived Hyperpolarizing Factor and Vascular Function. Cardiology Research and Practice No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-450242
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ozkor, Muhiddin A.& Quyyumi, Arshed A.. Endothelium-Derived Hyperpolarizing Factor and Vascular Function. Cardiology Research and Practice. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-450242
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-450242
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر