Endothelium-Derived Hyperpolarizing Factor and Vascular Function
Joint Authors
Ozkor, Muhiddin A.
Quyyumi, Arshed A.
Source
Cardiology Research and Practice
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-15
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Endothelial function refers to a multitude of physiological processes that maintain healthy homeostasis of the vascular wall.
Exposure of the endothelium to cardiac risk factors results in endothelial dysfunction and is associated with an alteration in the balance of vasoactive substances produced by endothelial cells.
These include a reduction in nitric oxide (NO), an increase in generation of potential vasoconstrictor substances and a potential compensatory increase in other mediators of vasodilation.
The latter has been surmised from data demonstrating persistent endothelium-dependent vasodilatation despite complete inhibition of NO and prostaglandins.
This remaining non-NO, non-prostaglandin mediated endothelium-dependent vasodilator response has been attributed to endothelium-derived hyperpolarizing factor/s (EDHF).
Endothelial hyperpolarization is likely due to several factors that appear to be site and species specific.
Experimental studies suggest that the contribution of the EDHFs increase as the vessel size decreases, with a predominance of EDHF activity in the resistance vessels, and a compensatory up-regulation of hyperpolarization in states characterized by reduced NO availability.
Since endothelial dysfunction is a precursor for atherosclerosis development and its magnitude is a reflection of future risk, then the mechanisms underlying endothelial dysfunction need to be fully understood, so that adequate therapeutic interventions can be designed.
American Psychological Association (APA)
Ozkor, Muhiddin A.& Quyyumi, Arshed A.. 2011. Endothelium-Derived Hyperpolarizing Factor and Vascular Function. Cardiology Research and Practice،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-450242
Modern Language Association (MLA)
Ozkor, Muhiddin A.& Quyyumi, Arshed A.. Endothelium-Derived Hyperpolarizing Factor and Vascular Function. Cardiology Research and Practice No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-450242
American Medical Association (AMA)
Ozkor, Muhiddin A.& Quyyumi, Arshed A.. Endothelium-Derived Hyperpolarizing Factor and Vascular Function. Cardiology Research and Practice. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-450242
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450242