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Osthole Attenuates Doxorubicin-Induced Apoptosis in PC12 Cells through Inhibition of Mitochondrial Dysfunction and ROS Production
المؤلفون المشاركون
Mohammadi-Motlagh, Hamid-Reza
Hosseinzadeh, Leila
Shokoohinia, Yalda
Mostafaie, Ali
Moieni-Arya, Maryam
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-12
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Doxorubicin (DOX) is a potent, broad-spectrum chemotherapeutic drug used for treatment of several types of cancers.
Despite its effectiveness, it has a wide range of toxic side effects, many of which most likely result from its inherent prooxidant activity.
It has been reported that DOX has toxic effects on normal tissues, including brain tissue.
In the current study, we investigated the protective effect of osthole isolated from Prangos ferulacea (L.) Lindl.
on oxidative stress and apoptosis induced by DOX in PC12 as a neuronal model cell line.
PC12 cells were pretreated with osthole 2 h after treatment with different concentrations of DOX.
24 h later, the cell viability, mitochondrial membrane potential (MMP), the activity of caspase-3, the expression ratio of Bax/Bcl-2, and the generation of intracellular ROS were detected.
We found that pretreatment with osthole on PC12 cells significantly reduced the loss of cell viability, the activity of caspase-3, the increase in Bax/Bcl-2 ratio, and the generation of intracellular ROS induced by DOX.
Moreover, pretreatment with osthole led to an increase in MMP in PC12 cells.
In conclusion, our results indicated that pretreatment with nontoxic concentrations of osthole protected PC12 cells from DOX-mediated apoptosis by inhibition of ROS production.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shokoohinia, Yalda& Hosseinzadeh, Leila& Moieni-Arya, Maryam& Mostafaie, Ali& Mohammadi-Motlagh, Hamid-Reza. 2014. Osthole Attenuates Doxorubicin-Induced Apoptosis in PC12 Cells through Inhibition of Mitochondrial Dysfunction and ROS Production. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-450312
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shokoohinia, Yalda…[et al.]. Osthole Attenuates Doxorubicin-Induced Apoptosis in PC12 Cells through Inhibition of Mitochondrial Dysfunction and ROS Production. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-450312
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shokoohinia, Yalda& Hosseinzadeh, Leila& Moieni-Arya, Maryam& Mostafaie, Ali& Mohammadi-Motlagh, Hamid-Reza. Osthole Attenuates Doxorubicin-Induced Apoptosis in PC12 Cells through Inhibition of Mitochondrial Dysfunction and ROS Production. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-450312
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-450312
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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