The Waveform Fluctuation and the Clinical Factors of the Initial and Sustained Erythropoietic Response to Continuous Erythropoietin Receptor Activator in Hemodialysis Patients
المؤلفون المشاركون
Liu, Wen-Sheng
Lin, Chih-Ching
Li, Szu-Yuan
Chen, Tzen-Wen
Yang, Wu-Chang
Wu, Yueh-Lin
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-04-19
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الطب البشري
تكنولوجيا المعلومات وعلم الحاسوب
الملخص EN
Objectives.
Erythropoiesis-stimulating agents (ESA) are the main treatment for anemia in hemodialysis (HD) patients.
We evaluated factors determining the response after treatment of a new ESA (continuous erythropoietin erythropoietin receptor activator (CERA)).
Methods.
61 HD patients were classified by their response at two different timings.
First, patients whose hematocrit (Hct) increased 1.5% in the first week were defined as initial responders (IR, n=16).
We compared several parameters between IR and the rest of the study subjects (non-IR, n=45).
Second, patients whose Hct increased 2% in the 4th week were defined as sustained responders (SR, n=12), and we did a similar comparison.
Results.
The Hct showed a waveform fluctuation.
Compared with the rest, IR had significantly lower platelet counts and higher levels of ferritin, total protein, total bilirubin, and serum sodium, while SR had significantly lower levels of C-reactive protein and low-density lipoprotein (All P<0.05).
In comparison with the rest, higher Hct persisted for 10 weeks in SR but only for two separate weeks (the 1st and 7th week) in IR.
Conclusions.
The initial and sustained erythropoietic responses are independent from each other and are associated with different factors.
Treatment focusing on these factors may improve the response.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Wen-Sheng& Wu, Yueh-Lin& Li, Szu-Yuan& Yang, Wu-Chang& Chen, Tzen-Wen& Lin, Chih-Ching. 2012. The Waveform Fluctuation and the Clinical Factors of the Initial and Sustained Erythropoietic Response to Continuous Erythropoietin Receptor Activator in Hemodialysis Patients. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-450379
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Wen-Sheng…[et al.]. The Waveform Fluctuation and the Clinical Factors of the Initial and Sustained Erythropoietic Response to Continuous Erythropoietin Receptor Activator in Hemodialysis Patients. The Scientific World Journal No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-450379
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Wen-Sheng& Wu, Yueh-Lin& Li, Szu-Yuan& Yang, Wu-Chang& Chen, Tzen-Wen& Lin, Chih-Ching. The Waveform Fluctuation and the Clinical Factors of the Initial and Sustained Erythropoietic Response to Continuous Erythropoietin Receptor Activator in Hemodialysis Patients. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-450379
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-450379
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر