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The Waveform Fluctuation and the Clinical Factors of the Initial and Sustained Erythropoietic Response to Continuous Erythropoietin Receptor Activator in Hemodialysis Patients
Joint Authors
Liu, Wen-Sheng
Lin, Chih-Ching
Li, Szu-Yuan
Chen, Tzen-Wen
Yang, Wu-Chang
Wu, Yueh-Lin
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-19
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
Objectives.
Erythropoiesis-stimulating agents (ESA) are the main treatment for anemia in hemodialysis (HD) patients.
We evaluated factors determining the response after treatment of a new ESA (continuous erythropoietin erythropoietin receptor activator (CERA)).
Methods.
61 HD patients were classified by their response at two different timings.
First, patients whose hematocrit (Hct) increased 1.5% in the first week were defined as initial responders (IR, n=16).
We compared several parameters between IR and the rest of the study subjects (non-IR, n=45).
Second, patients whose Hct increased 2% in the 4th week were defined as sustained responders (SR, n=12), and we did a similar comparison.
Results.
The Hct showed a waveform fluctuation.
Compared with the rest, IR had significantly lower platelet counts and higher levels of ferritin, total protein, total bilirubin, and serum sodium, while SR had significantly lower levels of C-reactive protein and low-density lipoprotein (All P<0.05).
In comparison with the rest, higher Hct persisted for 10 weeks in SR but only for two separate weeks (the 1st and 7th week) in IR.
Conclusions.
The initial and sustained erythropoietic responses are independent from each other and are associated with different factors.
Treatment focusing on these factors may improve the response.
American Psychological Association (APA)
Liu, Wen-Sheng& Wu, Yueh-Lin& Li, Szu-Yuan& Yang, Wu-Chang& Chen, Tzen-Wen& Lin, Chih-Ching. 2012. The Waveform Fluctuation and the Clinical Factors of the Initial and Sustained Erythropoietic Response to Continuous Erythropoietin Receptor Activator in Hemodialysis Patients. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-450379
Modern Language Association (MLA)
Liu, Wen-Sheng…[et al.]. The Waveform Fluctuation and the Clinical Factors of the Initial and Sustained Erythropoietic Response to Continuous Erythropoietin Receptor Activator in Hemodialysis Patients. The Scientific World Journal No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-450379
American Medical Association (AMA)
Liu, Wen-Sheng& Wu, Yueh-Lin& Li, Szu-Yuan& Yang, Wu-Chang& Chen, Tzen-Wen& Lin, Chih-Ching. The Waveform Fluctuation and the Clinical Factors of the Initial and Sustained Erythropoietic Response to Continuous Erythropoietin Receptor Activator in Hemodialysis Patients. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-450379
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450379