Tongguan Capsule Protects against Myocardial Ischemia and Reperfusion Injury in Mice
المؤلفون المشاركون
Zhou, Miao
Guo, Liheng
Wang, Lei
Zhang, Minzhou
Huang, Donghui
Yu, Juan
Qi, Jianyong
Wu, Jiashin
Ma, Shiyu
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-09-01
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Myocardial ischemia/reperfusion (I/R) can induce lethal ventricular arrhythmia and myocardial infarction.
One of the clinical strategies for managing patients with high risk of myocardial I/R is to prevent the occurrence of arrhythmias and limit the size of infarction following a coronary episode.
Tongguan Capsule (TGC) is one of the popular herbal remedies in treating coronary artery disease in the clinics of Chinese medicine.
However, the potential roles and mechanisms of TGC in reducing I/R injury are still unclear.
The present study statistically assessed the effectiveness of TGC in reducing I/R injury by comparing the infarct size (IS), risk region (RR), and arrhythmia (in electrocardiogram) among four groups of surgically created mice models of myocardial I/R: SHAM, I/R, VER (I/R with verapamil 20 mg/kg pretreatment), and TGC (I/R with TGC 5 g/kg/d pretreatment).
We found that IS was significantly smaller in the TGC and VER groups than I/R group, and the incidence of arrhythmias was reduced in the TGC group compared with I/R group, although there were no differences in RR among the four groups.
We conclude that TGC is effective in reducing I/R injury in mice.
These results provided an experimental basis for clinical application of TGC in reducing I/R injury.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Qi, Jianyong& Yu, Juan& Wang, Lei& Guo, Liheng& Ma, Shiyu& Huang, Donghui…[et al.]. 2013. Tongguan Capsule Protects against Myocardial Ischemia and Reperfusion Injury in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-450547
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Qi, Jianyong…[et al.]. Tongguan Capsule Protects against Myocardial Ischemia and Reperfusion Injury in Mice. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-450547
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Qi, Jianyong& Yu, Juan& Wang, Lei& Guo, Liheng& Ma, Shiyu& Huang, Donghui…[et al.]. Tongguan Capsule Protects against Myocardial Ischemia and Reperfusion Injury in Mice. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-450547
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-450547
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر