Tongguan Capsule Protects against Myocardial Ischemia and Reperfusion Injury in Mice
Joint Authors
Zhou, Miao
Guo, Liheng
Wang, Lei
Zhang, Minzhou
Huang, Donghui
Yu, Juan
Qi, Jianyong
Wu, Jiashin
Ma, Shiyu
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-01
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Myocardial ischemia/reperfusion (I/R) can induce lethal ventricular arrhythmia and myocardial infarction.
One of the clinical strategies for managing patients with high risk of myocardial I/R is to prevent the occurrence of arrhythmias and limit the size of infarction following a coronary episode.
Tongguan Capsule (TGC) is one of the popular herbal remedies in treating coronary artery disease in the clinics of Chinese medicine.
However, the potential roles and mechanisms of TGC in reducing I/R injury are still unclear.
The present study statistically assessed the effectiveness of TGC in reducing I/R injury by comparing the infarct size (IS), risk region (RR), and arrhythmia (in electrocardiogram) among four groups of surgically created mice models of myocardial I/R: SHAM, I/R, VER (I/R with verapamil 20 mg/kg pretreatment), and TGC (I/R with TGC 5 g/kg/d pretreatment).
We found that IS was significantly smaller in the TGC and VER groups than I/R group, and the incidence of arrhythmias was reduced in the TGC group compared with I/R group, although there were no differences in RR among the four groups.
We conclude that TGC is effective in reducing I/R injury in mice.
These results provided an experimental basis for clinical application of TGC in reducing I/R injury.
American Psychological Association (APA)
Qi, Jianyong& Yu, Juan& Wang, Lei& Guo, Liheng& Ma, Shiyu& Huang, Donghui…[et al.]. 2013. Tongguan Capsule Protects against Myocardial Ischemia and Reperfusion Injury in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-450547
Modern Language Association (MLA)
Qi, Jianyong…[et al.]. Tongguan Capsule Protects against Myocardial Ischemia and Reperfusion Injury in Mice. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-450547
American Medical Association (AMA)
Qi, Jianyong& Yu, Juan& Wang, Lei& Guo, Liheng& Ma, Shiyu& Huang, Donghui…[et al.]. Tongguan Capsule Protects against Myocardial Ischemia and Reperfusion Injury in Mice. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-450547
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450547