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Effect of the Combination of Gelam Honey and Ginger on Oxidative Stress and Metabolic Profile in Streptozotocin-Induced Diabetic Sprague-Dawley Rats
المؤلفون المشاركون
Mohd Yusof, Yasmin Anum
Abdul Sani, Nur Fathiah
Zar Chi, Thent
Belani, Levin Kesu
Makpol, Suzana
Das, Srijit
Abdul Rahman, Siti Nor Amilah
Pui Sin, Chong
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-04-16
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Diabetic complications occur as a result of increased reactive oxygen species (ROS) due to long term hyperglycaemia.
Honey and ginger have been shown to exhibit antioxidant activity which can scavenge ROS.
The main aim of this study was to evaluate the antioxidant and antidiabetic effects of gelam honey, ginger, and their combination.
Sprague-Dawley rats were divided into 2 major groups which consisted of diabetic and nondiabetic rats.
Diabetes was induced with streptozotocin intramuscularly (55 mg/kg body weight).
Each group was further divided into 4 smaller groups according to the supplements administered: distilled water, honey (2 g/kg body weight), ginger (60 mg/kg body weight), and honey + ginger.
Body weight and glucose levels were recorded weekly, while blood from the orbital sinus was obtained after 3 weeks of supplementation for the estimation of metabolic profile: glucose, triglyceride (TG), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH): oxidized glutathione (GSSG), and malondialdehyde (MDA).
The combination of gelam honey and ginger did not show hypoglycaemic potential; however, the combination treatment reduced significantly (P<0.05) SOD and CAT activities as well as MDA level, while GSH level and GSH/GSSG ratio were significantly elevated (P<0.05) in STZ-induced diabetic rats compared to diabetic control rats.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abdul Sani, Nur Fathiah& Belani, Levin Kesu& Pui Sin, Chong& Abdul Rahman, Siti Nor Amilah& Das, Srijit& Zar Chi, Thent…[et al.]. 2014. Effect of the Combination of Gelam Honey and Ginger on Oxidative Stress and Metabolic Profile in Streptozotocin-Induced Diabetic Sprague-Dawley Rats. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-450685
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abdul Sani, Nur Fathiah…[et al.]. Effect of the Combination of Gelam Honey and Ginger on Oxidative Stress and Metabolic Profile in Streptozotocin-Induced Diabetic Sprague-Dawley Rats. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-450685
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abdul Sani, Nur Fathiah& Belani, Levin Kesu& Pui Sin, Chong& Abdul Rahman, Siti Nor Amilah& Das, Srijit& Zar Chi, Thent…[et al.]. Effect of the Combination of Gelam Honey and Ginger on Oxidative Stress and Metabolic Profile in Streptozotocin-Induced Diabetic Sprague-Dawley Rats. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-450685
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-450685
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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