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Effect of the Combination of Gelam Honey and Ginger on Oxidative Stress and Metabolic Profile in Streptozotocin-Induced Diabetic Sprague-Dawley Rats
Joint Authors
Mohd Yusof, Yasmin Anum
Abdul Sani, Nur Fathiah
Zar Chi, Thent
Belani, Levin Kesu
Makpol, Suzana
Das, Srijit
Abdul Rahman, Siti Nor Amilah
Pui Sin, Chong
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-16
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Diabetic complications occur as a result of increased reactive oxygen species (ROS) due to long term hyperglycaemia.
Honey and ginger have been shown to exhibit antioxidant activity which can scavenge ROS.
The main aim of this study was to evaluate the antioxidant and antidiabetic effects of gelam honey, ginger, and their combination.
Sprague-Dawley rats were divided into 2 major groups which consisted of diabetic and nondiabetic rats.
Diabetes was induced with streptozotocin intramuscularly (55 mg/kg body weight).
Each group was further divided into 4 smaller groups according to the supplements administered: distilled water, honey (2 g/kg body weight), ginger (60 mg/kg body weight), and honey + ginger.
Body weight and glucose levels were recorded weekly, while blood from the orbital sinus was obtained after 3 weeks of supplementation for the estimation of metabolic profile: glucose, triglyceride (TG), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH): oxidized glutathione (GSSG), and malondialdehyde (MDA).
The combination of gelam honey and ginger did not show hypoglycaemic potential; however, the combination treatment reduced significantly (P<0.05) SOD and CAT activities as well as MDA level, while GSH level and GSH/GSSG ratio were significantly elevated (P<0.05) in STZ-induced diabetic rats compared to diabetic control rats.
American Psychological Association (APA)
Abdul Sani, Nur Fathiah& Belani, Levin Kesu& Pui Sin, Chong& Abdul Rahman, Siti Nor Amilah& Das, Srijit& Zar Chi, Thent…[et al.]. 2014. Effect of the Combination of Gelam Honey and Ginger on Oxidative Stress and Metabolic Profile in Streptozotocin-Induced Diabetic Sprague-Dawley Rats. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-450685
Modern Language Association (MLA)
Abdul Sani, Nur Fathiah…[et al.]. Effect of the Combination of Gelam Honey and Ginger on Oxidative Stress and Metabolic Profile in Streptozotocin-Induced Diabetic Sprague-Dawley Rats. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-450685
American Medical Association (AMA)
Abdul Sani, Nur Fathiah& Belani, Levin Kesu& Pui Sin, Chong& Abdul Rahman, Siti Nor Amilah& Das, Srijit& Zar Chi, Thent…[et al.]. Effect of the Combination of Gelam Honey and Ginger on Oxidative Stress and Metabolic Profile in Streptozotocin-Induced Diabetic Sprague-Dawley Rats. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-450685
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450685