Detecting Early Biomechanical Effects of Zoledronic Acid on Femurs of Osteoporotic Female Rats
المؤلفون المشاركون
Palacio, Evandro Pereira
Sardenberg, Trajano
Müller, Sérgio Swain
Mizobuchi, Roberto Ryuiti
Savarese, Aniello
Durigan, Alcides
Ortolan, Érika Veruska Paiva
Galbiatti, José Antônio
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-12-04
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Aim.
To investigate the biomechanical effects of zoledronic acid (ZA) on femurs of female osteoporotic rats after follow-up periods of 9 and 12 months.
Methods.
Eighty female Wistar rats were prospectively assessed.
At 60 days of age, the animals were randomly divided into two groups: bilateral oophorectomy (O) (n=40) and sham surgery (S) (n=40).
At 90 days of age, groups O and S were randomly subdivided into four groups, according to whether 0.1 mg/kg of ZA or distilled water (DW) was intraperitoneally administered: OZA (n=20), ODW (n=20), SZA (n=20), and SDW (n=20).
The animals were sacrificed at 9 and 12 months after the administration of the substances, and then their right femurs were removed and analyzed biomechanically.
Axial compression tests that focused on determining the maximum load (N), yield point (N), and stiffness coefficient (N/mm) of the proximal femur were performed in the biomechanical study.
Results.
ZA significantly increased the maximum load and yield point, reducing the stiffness coefficient concerning the oophorectomy status and follow-up period.
Conclusion.
Zoledronic acid, at a dose of 0.1 mg/kg, significantly increased the maximum loads and yield points and reduced the stiffness coefficients in the femurs of female rats with osteoporosis caused by bilateral oophorectomy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Palacio, Evandro Pereira& Müller, Sérgio Swain& Sardenberg, Trajano& Mizobuchi, Roberto Ryuiti& Galbiatti, José Antônio& Durigan, Alcides…[et al.]. 2012. Detecting Early Biomechanical Effects of Zoledronic Acid on Femurs of Osteoporotic Female Rats. Journal of Osteoporosis،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-450859
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Palacio, Evandro Pereira…[et al.]. Detecting Early Biomechanical Effects of Zoledronic Acid on Femurs of Osteoporotic Female Rats. Journal of Osteoporosis No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-450859
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Palacio, Evandro Pereira& Müller, Sérgio Swain& Sardenberg, Trajano& Mizobuchi, Roberto Ryuiti& Galbiatti, José Antônio& Durigan, Alcides…[et al.]. Detecting Early Biomechanical Effects of Zoledronic Acid on Femurs of Osteoporotic Female Rats. Journal of Osteoporosis. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-450859
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-450859
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر