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Detecting Early Biomechanical Effects of Zoledronic Acid on Femurs of Osteoporotic Female Rats
Joint Authors
Palacio, Evandro Pereira
Sardenberg, Trajano
Müller, Sérgio Swain
Mizobuchi, Roberto Ryuiti
Savarese, Aniello
Durigan, Alcides
Ortolan, Érika Veruska Paiva
Galbiatti, José Antônio
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Aim.
To investigate the biomechanical effects of zoledronic acid (ZA) on femurs of female osteoporotic rats after follow-up periods of 9 and 12 months.
Methods.
Eighty female Wistar rats were prospectively assessed.
At 60 days of age, the animals were randomly divided into two groups: bilateral oophorectomy (O) (n=40) and sham surgery (S) (n=40).
At 90 days of age, groups O and S were randomly subdivided into four groups, according to whether 0.1 mg/kg of ZA or distilled water (DW) was intraperitoneally administered: OZA (n=20), ODW (n=20), SZA (n=20), and SDW (n=20).
The animals were sacrificed at 9 and 12 months after the administration of the substances, and then their right femurs were removed and analyzed biomechanically.
Axial compression tests that focused on determining the maximum load (N), yield point (N), and stiffness coefficient (N/mm) of the proximal femur were performed in the biomechanical study.
Results.
ZA significantly increased the maximum load and yield point, reducing the stiffness coefficient concerning the oophorectomy status and follow-up period.
Conclusion.
Zoledronic acid, at a dose of 0.1 mg/kg, significantly increased the maximum loads and yield points and reduced the stiffness coefficients in the femurs of female rats with osteoporosis caused by bilateral oophorectomy.
American Psychological Association (APA)
Palacio, Evandro Pereira& Müller, Sérgio Swain& Sardenberg, Trajano& Mizobuchi, Roberto Ryuiti& Galbiatti, José Antônio& Durigan, Alcides…[et al.]. 2012. Detecting Early Biomechanical Effects of Zoledronic Acid on Femurs of Osteoporotic Female Rats. Journal of Osteoporosis،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-450859
Modern Language Association (MLA)
Palacio, Evandro Pereira…[et al.]. Detecting Early Biomechanical Effects of Zoledronic Acid on Femurs of Osteoporotic Female Rats. Journal of Osteoporosis No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-450859
American Medical Association (AMA)
Palacio, Evandro Pereira& Müller, Sérgio Swain& Sardenberg, Trajano& Mizobuchi, Roberto Ryuiti& Galbiatti, José Antônio& Durigan, Alcides…[et al.]. Detecting Early Biomechanical Effects of Zoledronic Acid on Femurs of Osteoporotic Female Rats. Journal of Osteoporosis. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-450859
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450859