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Novel Role of Parathyroid Hormone-Related Protein in the Pathophysiology of the Diabetic Kidney : Evidence from Experimental and Human Diabetic Nephropathy
المؤلفون المشاركون
Bover, Jordi
Olea, Nuria
Arenas, María Isabel
Esbrit, Pedro
Ortega, Arantxa
Bosch, Ricardo J.
Romero, Montserrat
Izquierdo, Adriana
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-07-31
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Parathyroid hormone-related protein (PTHrP) and its receptor type 1 (PTH1R) are extensively expressed in the kidney, where they are able to modulate renal function.
Renal PTHrP is known to be overexpressed in acute renal injury.
Recently, we hypothesized that PTHrP involvement in the mechanisms of renal injury might not be limited to conditions with predominant damage of the renal tubulointerstitium and might be extended to glomerular diseases, such as diabetic nephropathy (DN).
In experimental DN, the overexpression of both PTHrP and the PTH1R contributes to the development of renal hypertrophy as well as proteinuria.
More recent data have shown, for the first time, that PTHrP is upregulated in the kidney from patients with DN.
Collectively, animal and human studies have shown that PTHrP acts as an important mediator of diabetic renal cell hypertrophy by a mechanism which involves the modulation of cell cycle regulatory proteins and TGF-β1.
Furthermore, angiotensin II (Ang II), a critical factor in the progression of renal injury, appears to be responsible for PTHrP upregulation in these conditions.
These findings provide novel insights into the well-known protective effects of Ang II antagonists in renal diseases, paving the way for new therapeutic approaches.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Romero, Montserrat& Ortega, Arantxa& Olea, Nuria& Arenas, María Isabel& Izquierdo, Adriana& Bover, Jordi…[et al.]. 2013. Novel Role of Parathyroid Hormone-Related Protein in the Pathophysiology of the Diabetic Kidney : Evidence from Experimental and Human Diabetic Nephropathy. Journal of Diabetes Research،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-450864
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Romero, Montserrat…[et al.]. Novel Role of Parathyroid Hormone-Related Protein in the Pathophysiology of the Diabetic Kidney : Evidence from Experimental and Human Diabetic Nephropathy. Journal of Diabetes Research No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-450864
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Romero, Montserrat& Ortega, Arantxa& Olea, Nuria& Arenas, María Isabel& Izquierdo, Adriana& Bover, Jordi…[et al.]. Novel Role of Parathyroid Hormone-Related Protein in the Pathophysiology of the Diabetic Kidney : Evidence from Experimental and Human Diabetic Nephropathy. Journal of Diabetes Research. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-450864
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-450864
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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