Novel Role of Parathyroid Hormone-Related Protein in the Pathophysiology of the Diabetic Kidney : Evidence from Experimental and Human Diabetic Nephropathy
Joint Authors
Bover, Jordi
Olea, Nuria
Arenas, María Isabel
Esbrit, Pedro
Ortega, Arantxa
Bosch, Ricardo J.
Romero, Montserrat
Izquierdo, Adriana
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-31
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Parathyroid hormone-related protein (PTHrP) and its receptor type 1 (PTH1R) are extensively expressed in the kidney, where they are able to modulate renal function.
Renal PTHrP is known to be overexpressed in acute renal injury.
Recently, we hypothesized that PTHrP involvement in the mechanisms of renal injury might not be limited to conditions with predominant damage of the renal tubulointerstitium and might be extended to glomerular diseases, such as diabetic nephropathy (DN).
In experimental DN, the overexpression of both PTHrP and the PTH1R contributes to the development of renal hypertrophy as well as proteinuria.
More recent data have shown, for the first time, that PTHrP is upregulated in the kidney from patients with DN.
Collectively, animal and human studies have shown that PTHrP acts as an important mediator of diabetic renal cell hypertrophy by a mechanism which involves the modulation of cell cycle regulatory proteins and TGF-β1.
Furthermore, angiotensin II (Ang II), a critical factor in the progression of renal injury, appears to be responsible for PTHrP upregulation in these conditions.
These findings provide novel insights into the well-known protective effects of Ang II antagonists in renal diseases, paving the way for new therapeutic approaches.
American Psychological Association (APA)
Romero, Montserrat& Ortega, Arantxa& Olea, Nuria& Arenas, María Isabel& Izquierdo, Adriana& Bover, Jordi…[et al.]. 2013. Novel Role of Parathyroid Hormone-Related Protein in the Pathophysiology of the Diabetic Kidney : Evidence from Experimental and Human Diabetic Nephropathy. Journal of Diabetes Research،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-450864
Modern Language Association (MLA)
Romero, Montserrat…[et al.]. Novel Role of Parathyroid Hormone-Related Protein in the Pathophysiology of the Diabetic Kidney : Evidence from Experimental and Human Diabetic Nephropathy. Journal of Diabetes Research No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-450864
American Medical Association (AMA)
Romero, Montserrat& Ortega, Arantxa& Olea, Nuria& Arenas, María Isabel& Izquierdo, Adriana& Bover, Jordi…[et al.]. Novel Role of Parathyroid Hormone-Related Protein in the Pathophysiology of the Diabetic Kidney : Evidence from Experimental and Human Diabetic Nephropathy. Journal of Diabetes Research. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-450864
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450864