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High Blood Pressure Effects on the Blood to Cerebrospinal Fluid Barrier and Cerebrospinal Fluid Protein Composition : A Two-Dimensional Electrophoresis Study in Spontaneously Hypertensive Rats
المؤلفون المشاركون
Castañeyra-Perdomo, Agustín
Carmona-Calero, Emilia M.
González-Marrero, Ibrahim
Castañeyra-Ruiz, Leandro
Castro, Rafael
Hernandez-Fernaud, Juan R.
de Paz-Carmona, Hector
Castañeyra-Ruiz, Agustín
González-Toledo, Juan M.
المصدر
International Journal of Hypertension
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-01-21
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The aim of the present work is to analyze the cerebrospinal fluid proteomic profile, trying to find possible biomarkers of the effects of hypertension of the blood to CSF barrier disruption in the brain and their participation in the cholesterol and β-amyloid metabolism and inflammatory processes.
Cerebrospinal fluid (CSF) is a system linked to the brain and its composition can be altered not only by encephalic disorder, but also by systemic diseases such as arterial hypertension, which produces alterations in the choroid plexus and cerebrospinal fluid protein composition.
2D gel electrophoresis in cerebrospinal fluid extracted from the cistern magna before sacrifice of hypertensive and control rats was performed.
The results showed different proteomic profiles between SHR and WKY, that α-1-antitrypsin, apolipoprotein A1, albumin, immunoglobulin G, vitamin D binding protein, haptoglobin and α-1-macroglobulin were found to be up-regulated in SHR, and apolipoprotein E, transthyretin, α-2-HS-glycoprotein, transferrin, α-1β-glycoprotein, kininogen and carbonic anhidrase II were down-regulated in SHR.
The conclusion made here is that hypertension in SHR produces important variations in cerebrospinal fluid proteins that could be due to a choroid plexus dysfunction and this fact supports the close connection between hypertension and blood to cerebrospinal fluid barrier disruption.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
González-Marrero, Ibrahim& Castañeyra-Ruiz, Leandro& González-Toledo, Juan M.& Castañeyra-Ruiz, Agustín& de Paz-Carmona, Hector& Castro, Rafael…[et al.]. 2013. High Blood Pressure Effects on the Blood to Cerebrospinal Fluid Barrier and Cerebrospinal Fluid Protein Composition : A Two-Dimensional Electrophoresis Study in Spontaneously Hypertensive Rats. International Journal of Hypertension،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-451030
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
González-Marrero, Ibrahim…[et al.]. High Blood Pressure Effects on the Blood to Cerebrospinal Fluid Barrier and Cerebrospinal Fluid Protein Composition : A Two-Dimensional Electrophoresis Study in Spontaneously Hypertensive Rats. International Journal of Hypertension No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-451030
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
González-Marrero, Ibrahim& Castañeyra-Ruiz, Leandro& González-Toledo, Juan M.& Castañeyra-Ruiz, Agustín& de Paz-Carmona, Hector& Castro, Rafael…[et al.]. High Blood Pressure Effects on the Blood to Cerebrospinal Fluid Barrier and Cerebrospinal Fluid Protein Composition : A Two-Dimensional Electrophoresis Study in Spontaneously Hypertensive Rats. International Journal of Hypertension. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-451030
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-451030
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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