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High Blood Pressure Effects on the Blood to Cerebrospinal Fluid Barrier and Cerebrospinal Fluid Protein Composition : A Two-Dimensional Electrophoresis Study in Spontaneously Hypertensive Rats
Joint Authors
Castañeyra-Perdomo, Agustín
Carmona-Calero, Emilia M.
González-Marrero, Ibrahim
Castañeyra-Ruiz, Leandro
Castro, Rafael
Hernandez-Fernaud, Juan R.
de Paz-Carmona, Hector
Castañeyra-Ruiz, Agustín
González-Toledo, Juan M.
Source
International Journal of Hypertension
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-21
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The aim of the present work is to analyze the cerebrospinal fluid proteomic profile, trying to find possible biomarkers of the effects of hypertension of the blood to CSF barrier disruption in the brain and their participation in the cholesterol and β-amyloid metabolism and inflammatory processes.
Cerebrospinal fluid (CSF) is a system linked to the brain and its composition can be altered not only by encephalic disorder, but also by systemic diseases such as arterial hypertension, which produces alterations in the choroid plexus and cerebrospinal fluid protein composition.
2D gel electrophoresis in cerebrospinal fluid extracted from the cistern magna before sacrifice of hypertensive and control rats was performed.
The results showed different proteomic profiles between SHR and WKY, that α-1-antitrypsin, apolipoprotein A1, albumin, immunoglobulin G, vitamin D binding protein, haptoglobin and α-1-macroglobulin were found to be up-regulated in SHR, and apolipoprotein E, transthyretin, α-2-HS-glycoprotein, transferrin, α-1β-glycoprotein, kininogen and carbonic anhidrase II were down-regulated in SHR.
The conclusion made here is that hypertension in SHR produces important variations in cerebrospinal fluid proteins that could be due to a choroid plexus dysfunction and this fact supports the close connection between hypertension and blood to cerebrospinal fluid barrier disruption.
American Psychological Association (APA)
González-Marrero, Ibrahim& Castañeyra-Ruiz, Leandro& González-Toledo, Juan M.& Castañeyra-Ruiz, Agustín& de Paz-Carmona, Hector& Castro, Rafael…[et al.]. 2013. High Blood Pressure Effects on the Blood to Cerebrospinal Fluid Barrier and Cerebrospinal Fluid Protein Composition : A Two-Dimensional Electrophoresis Study in Spontaneously Hypertensive Rats. International Journal of Hypertension،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-451030
Modern Language Association (MLA)
González-Marrero, Ibrahim…[et al.]. High Blood Pressure Effects on the Blood to Cerebrospinal Fluid Barrier and Cerebrospinal Fluid Protein Composition : A Two-Dimensional Electrophoresis Study in Spontaneously Hypertensive Rats. International Journal of Hypertension No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-451030
American Medical Association (AMA)
González-Marrero, Ibrahim& Castañeyra-Ruiz, Leandro& González-Toledo, Juan M.& Castañeyra-Ruiz, Agustín& de Paz-Carmona, Hector& Castro, Rafael…[et al.]. High Blood Pressure Effects on the Blood to Cerebrospinal Fluid Barrier and Cerebrospinal Fluid Protein Composition : A Two-Dimensional Electrophoresis Study in Spontaneously Hypertensive Rats. International Journal of Hypertension. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-451030
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-451030