Circulating Prostate Cells Found in Men with Benign Prostate Disease Are P504S Negative : Clinical Implications

المؤلفون المشاركون

Dueñas, Ricardo
Badínez, Leonardo
Murray, Nigel P.
Fuentealba, Cynthia
Olivares, Ruben
Reyes, Eduardo
Porcell, José
Orellana, Nelson

المصدر

Journal of Oncology

العدد

المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-5، 5ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2013-04-17

دولة النشر

مصر

عدد الصفحات

5

التخصصات الرئيسية

الأمراض
الطب البشري

الملخص EN

Introduction.

Developments in immunological and quantitative real-time PCR-based analysis have enabled the detection, enumeration, and characterization of circulating tumor cells (CTCs).

It is assumed that the detection of CTCs is associated with cancer, based on the finding that CTCs can be detected in all major cancer and not in healthy subjects or those with benign disease.

Methods and Patients.

Consecutive men, with suspicion of prostate cancer, had blood samples taken before prostate biopsy; mononuclear cells were obtained using differential gel centrifugation and CPCs detecting using anti-PSA immunocytochemistry.

Positive samples underwent further classification with anti-P504S.

Results.

329 men underwent prostate biopsy; of these men 83 underwent a second biopsy and 44 a third one.

Of those with a biopsy negative for cancer, 19/226 (8.4%) had CPCs PSA (+) P504S (−) detected at first biopsy, 6/74 (8.1%) at second biopsy, and 5/33 (15.2%) at third biopsy.

Men with cancer-positive biopsies did not have PSA (+) P504S (−) CPCs detected.

These benign cells were associated with chronic prostatitis.

Conclusions.

Patients with chronic prostatitis may have circulating prostate cells detected in blood, which do not express the enzyme P504S and should be thought of as benign in nature.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Murray, Nigel P.& Reyes, Eduardo& Badínez, Leonardo& Orellana, Nelson& Fuentealba, Cynthia& Olivares, Ruben…[et al.]. 2013. Circulating Prostate Cells Found in Men with Benign Prostate Disease Are P504S Negative : Clinical Implications. Journal of Oncology،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-451075

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Murray, Nigel P.…[et al.]. Circulating Prostate Cells Found in Men with Benign Prostate Disease Are P504S Negative : Clinical Implications. Journal of Oncology No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-451075

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Murray, Nigel P.& Reyes, Eduardo& Badínez, Leonardo& Orellana, Nelson& Fuentealba, Cynthia& Olivares, Ruben…[et al.]. Circulating Prostate Cells Found in Men with Benign Prostate Disease Are P504S Negative : Clinical Implications. Journal of Oncology. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-451075

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-451075