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Circulating Prostate Cells Found in Men with Benign Prostate Disease Are P504S Negative : Clinical Implications
Joint Authors
Dueñas, Ricardo
Badínez, Leonardo
Murray, Nigel P.
Fuentealba, Cynthia
Olivares, Ruben
Reyes, Eduardo
Porcell, José
Orellana, Nelson
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-17
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Introduction.
Developments in immunological and quantitative real-time PCR-based analysis have enabled the detection, enumeration, and characterization of circulating tumor cells (CTCs).
It is assumed that the detection of CTCs is associated with cancer, based on the finding that CTCs can be detected in all major cancer and not in healthy subjects or those with benign disease.
Methods and Patients.
Consecutive men, with suspicion of prostate cancer, had blood samples taken before prostate biopsy; mononuclear cells were obtained using differential gel centrifugation and CPCs detecting using anti-PSA immunocytochemistry.
Positive samples underwent further classification with anti-P504S.
Results.
329 men underwent prostate biopsy; of these men 83 underwent a second biopsy and 44 a third one.
Of those with a biopsy negative for cancer, 19/226 (8.4%) had CPCs PSA (+) P504S (−) detected at first biopsy, 6/74 (8.1%) at second biopsy, and 5/33 (15.2%) at third biopsy.
Men with cancer-positive biopsies did not have PSA (+) P504S (−) CPCs detected.
These benign cells were associated with chronic prostatitis.
Conclusions.
Patients with chronic prostatitis may have circulating prostate cells detected in blood, which do not express the enzyme P504S and should be thought of as benign in nature.
American Psychological Association (APA)
Murray, Nigel P.& Reyes, Eduardo& Badínez, Leonardo& Orellana, Nelson& Fuentealba, Cynthia& Olivares, Ruben…[et al.]. 2013. Circulating Prostate Cells Found in Men with Benign Prostate Disease Are P504S Negative : Clinical Implications. Journal of Oncology،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-451075
Modern Language Association (MLA)
Murray, Nigel P.…[et al.]. Circulating Prostate Cells Found in Men with Benign Prostate Disease Are P504S Negative : Clinical Implications. Journal of Oncology No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-451075
American Medical Association (AMA)
Murray, Nigel P.& Reyes, Eduardo& Badínez, Leonardo& Orellana, Nelson& Fuentealba, Cynthia& Olivares, Ruben…[et al.]. Circulating Prostate Cells Found in Men with Benign Prostate Disease Are P504S Negative : Clinical Implications. Journal of Oncology. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-451075
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-451075