Identification of a New Peptide for Fibrosarcoma Tumor Targeting and Imaging In Vivo

المؤلفون المشاركون

Wu, Chih-Hsiung
Sun, Ming-Ding
Lee, Yu-Ching
Luo, Tsai-Yueh
Wu, Chia-Che
Lin, Erh-Hsuan
Fu, Ying-Kai
Deng, Win-Ping
Leu, Sy-Jye
Chen, Haw-Jan
Wang, Hsin-Ell
WU, Cheng-Wen
Tai, Cheng-Jeng
Kuo, Tsu-Hsiang

المصدر

Journal of Biomedicine and Biotechnology

العدد

المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-10، 10ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2010-12-05

دولة النشر

مصر

عدد الصفحات

10

التخصصات الرئيسية

الطب البشري

الملخص EN

A 12-mer amino acid peptide SATTHYRLQAAN, denominated TK4, was isolated from a phage-display library with fibrosarcoma tumor-binding activity.

In vivo biodistribution analysis of TK4-displaying phage showed a significant increased phage titer in implanted tumor up to 10-fold in comparison with normal tissues after systemic administration in mouse.

Competition assay confirmed that the binding of TK4-phage to tumor cells depends on the TK4 peptide.

Intravenous injection of 131I-labeled synthetic TK4 peptide in mice showed a tumor retention of 3.3% and 2.7% ID/g at 1- and 4-hour postinjection, respectively.

Tumor-to-muscle ratio was 1.1, 5.7, and 3.2 at 1-, 4-, and 24-hour, respectively, and tumors were imaged on a digital γ-camera at 4-hour postinjection.

The present data suggest that TK4 holds promise as a lead structure for tumor targeting, and it could be further applied in the development of diagnostic or therapeutic agent.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Wu, Chia-Che& Lin, Erh-Hsuan& Lee, Yu-Ching& Tai, Cheng-Jeng& Kuo, Tsu-Hsiang& Wang, Hsin-Ell…[et al.]. 2010. Identification of a New Peptide for Fibrosarcoma Tumor Targeting and Imaging In Vivo. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-451178

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Wu, Chia-Che…[et al.]. Identification of a New Peptide for Fibrosarcoma Tumor Targeting and Imaging In Vivo. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-451178

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Wu, Chia-Che& Lin, Erh-Hsuan& Lee, Yu-Ching& Tai, Cheng-Jeng& Kuo, Tsu-Hsiang& Wang, Hsin-Ell…[et al.]. Identification of a New Peptide for Fibrosarcoma Tumor Targeting and Imaging In Vivo. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-451178

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-451178