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Identification of a New Peptide for Fibrosarcoma Tumor Targeting and Imaging In Vivo
Joint Authors
Wu, Chih-Hsiung
Sun, Ming-Ding
Lee, Yu-Ching
Luo, Tsai-Yueh
Wu, Chia-Che
Lin, Erh-Hsuan
Fu, Ying-Kai
Deng, Win-Ping
Leu, Sy-Jye
Chen, Haw-Jan
Wang, Hsin-Ell
WU, Cheng-Wen
Tai, Cheng-Jeng
Kuo, Tsu-Hsiang
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-05
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
A 12-mer amino acid peptide SATTHYRLQAAN, denominated TK4, was isolated from a phage-display library with fibrosarcoma tumor-binding activity.
In vivo biodistribution analysis of TK4-displaying phage showed a significant increased phage titer in implanted tumor up to 10-fold in comparison with normal tissues after systemic administration in mouse.
Competition assay confirmed that the binding of TK4-phage to tumor cells depends on the TK4 peptide.
Intravenous injection of 131I-labeled synthetic TK4 peptide in mice showed a tumor retention of 3.3% and 2.7% ID/g at 1- and 4-hour postinjection, respectively.
Tumor-to-muscle ratio was 1.1, 5.7, and 3.2 at 1-, 4-, and 24-hour, respectively, and tumors were imaged on a digital γ-camera at 4-hour postinjection.
The present data suggest that TK4 holds promise as a lead structure for tumor targeting, and it could be further applied in the development of diagnostic or therapeutic agent.
American Psychological Association (APA)
Wu, Chia-Che& Lin, Erh-Hsuan& Lee, Yu-Ching& Tai, Cheng-Jeng& Kuo, Tsu-Hsiang& Wang, Hsin-Ell…[et al.]. 2010. Identification of a New Peptide for Fibrosarcoma Tumor Targeting and Imaging In Vivo. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-451178
Modern Language Association (MLA)
Wu, Chia-Che…[et al.]. Identification of a New Peptide for Fibrosarcoma Tumor Targeting and Imaging In Vivo. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-451178
American Medical Association (AMA)
Wu, Chia-Che& Lin, Erh-Hsuan& Lee, Yu-Ching& Tai, Cheng-Jeng& Kuo, Tsu-Hsiang& Wang, Hsin-Ell…[et al.]. Identification of a New Peptide for Fibrosarcoma Tumor Targeting and Imaging In Vivo. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-451178
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-451178