Age-Associated Molecular Changes in the Kidney in Aged Mice
المؤلفون المشاركون
Kim, Eun Nim
Yang, Chul Woo
Kim, Min Young
Park, Cheol Whee
Choi, Bum Soon
Lim, Ji Hee
Kim, Yong-Soo
Kim, Hyung Wook
Chang, Yoon Sik
Chung, Sungjin
Shin, Seok Joon
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-12-30
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الأحياء
الملخص EN
Background.
Aging is a multifactorial process characterized by a progressive decline in physiological function.
Decreased kidney function is associated with cardiovascular disease and mortality.
Therefore, increasing our insight into kidney aging by understanding the anatomic, physiologic, and pathologic changes of aging in the kidney is important to prevent disastrous outcomes in elderly people.
Methods.
Male two-, 12-, and 24-month-old C57/BL6 mice were used in this study.
We measured histological change, oxidative stress, and aging-related protein expression in the kidneys.
Results.
Twenty-four-month-old mice displayed increased albuminuria.
Creatinine clearance decreased with aging, although this was not statistically significant.
There were increases in mesangial volume and tubulointerstitial fibrosis in 24-month-old mice.
There were also increases in F4/80 expression and in apoptosis detected by TUNEL assay.
Urine isoprostane excretion increased with aging and SOD1 and SOD2 were decreased in 24-month-old mice.
Oxidative stress may be mediated by a decrease in Sirt1, PGC-1α, ERR-1α, and PPARα expression.
Klotho expression also decreased.
Conclusions.
Our results demonstrate that Sirt1 was decreased with aging and may relate to changed target molecules including PGC-1α/ERR-1α signaling and PPARα.
Klotho can also induce oxidative stress.
Pharmacologically targeting these signaling molecules may reduce the pathologic changes of aging in the kidney.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lim, Ji Hee& Kim, Eun Nim& Kim, Min Young& Chung, Sungjin& Shin, Seok Joon& Kim, Hyung Wook…[et al.]. 2012. Age-Associated Molecular Changes in the Kidney in Aged Mice. Oxidative Medicine and Cellular Longevity،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-451563
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lim, Ji Hee…[et al.]. Age-Associated Molecular Changes in the Kidney in Aged Mice. Oxidative Medicine and Cellular Longevity No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-451563
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lim, Ji Hee& Kim, Eun Nim& Kim, Min Young& Chung, Sungjin& Shin, Seok Joon& Kim, Hyung Wook…[et al.]. Age-Associated Molecular Changes in the Kidney in Aged Mice. Oxidative Medicine and Cellular Longevity. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-451563
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-451563
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر