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Age-Associated Molecular Changes in the Kidney in Aged Mice
Joint Authors
Kim, Eun Nim
Yang, Chul Woo
Kim, Min Young
Park, Cheol Whee
Choi, Bum Soon
Lim, Ji Hee
Kim, Yong-Soo
Kim, Hyung Wook
Chang, Yoon Sik
Chung, Sungjin
Shin, Seok Joon
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-30
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Background.
Aging is a multifactorial process characterized by a progressive decline in physiological function.
Decreased kidney function is associated with cardiovascular disease and mortality.
Therefore, increasing our insight into kidney aging by understanding the anatomic, physiologic, and pathologic changes of aging in the kidney is important to prevent disastrous outcomes in elderly people.
Methods.
Male two-, 12-, and 24-month-old C57/BL6 mice were used in this study.
We measured histological change, oxidative stress, and aging-related protein expression in the kidneys.
Results.
Twenty-four-month-old mice displayed increased albuminuria.
Creatinine clearance decreased with aging, although this was not statistically significant.
There were increases in mesangial volume and tubulointerstitial fibrosis in 24-month-old mice.
There were also increases in F4/80 expression and in apoptosis detected by TUNEL assay.
Urine isoprostane excretion increased with aging and SOD1 and SOD2 were decreased in 24-month-old mice.
Oxidative stress may be mediated by a decrease in Sirt1, PGC-1α, ERR-1α, and PPARα expression.
Klotho expression also decreased.
Conclusions.
Our results demonstrate that Sirt1 was decreased with aging and may relate to changed target molecules including PGC-1α/ERR-1α signaling and PPARα.
Klotho can also induce oxidative stress.
Pharmacologically targeting these signaling molecules may reduce the pathologic changes of aging in the kidney.
American Psychological Association (APA)
Lim, Ji Hee& Kim, Eun Nim& Kim, Min Young& Chung, Sungjin& Shin, Seok Joon& Kim, Hyung Wook…[et al.]. 2012. Age-Associated Molecular Changes in the Kidney in Aged Mice. Oxidative Medicine and Cellular Longevity،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-451563
Modern Language Association (MLA)
Lim, Ji Hee…[et al.]. Age-Associated Molecular Changes in the Kidney in Aged Mice. Oxidative Medicine and Cellular Longevity No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-451563
American Medical Association (AMA)
Lim, Ji Hee& Kim, Eun Nim& Kim, Min Young& Chung, Sungjin& Shin, Seok Joon& Kim, Hyung Wook…[et al.]. Age-Associated Molecular Changes in the Kidney in Aged Mice. Oxidative Medicine and Cellular Longevity. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-451563
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-451563