Peroxisome Proliferator-Activated Receptor Delta : A Conserved Director of Lipid Homeostasis through Regulation of the Oxidative Capacity of Muscle

المؤلفون المشاركون

de Lange, Pieter
Silvestri, Elena
Moreno, Maria
Lanni, Antonia
Lombardi, Assunta
Goglia, Fernando

المصدر

PPAR Research

العدد

المجلد 2008، العدد 2008 (31 ديسمبر/كانون الأول 2008)، ص ص. 1-7، 7ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2008-09-22

دولة النشر

مصر

عدد الصفحات

7

التخصصات الرئيسية

العلوم الطبيعية والحياتية (متداخلة التخصصات)
الأحياء

الملخص EN

The peroxisome proliferator-activated receptors (PPARs), which are ligand-inducible transcription factors expressed in a variety of tissues, have been shown to perform key roles in lipid homeostasis.

In physiological situations such as fasting and physical exercise, one PPAR subtype, PPARδ, triggers a transcriptional program in skeletal muscle leading to a switch in fuel usage from glucose/fatty acids to solely fatty acids, thereby drastically increasing its oxidative capacity.

The metabolic action of PPARδ has also been verified in humans.

In addition, it has become clear that the action of PPARδ is not restricted to skeletal muscle.

Indeed, PPARδ has been shown to play a crucial role in whole-body lipid homeostasis as well as in insulin sensitivity, and it is active not only in skeletal muscle (as an activator of fat burning) but also in the liver (where it can activate glycolysis/lipogenesis, with the produced fat being oxidized in muscle) and in the adipose tissue (by incrementing lipolysis).

The main aim of this review is to highlight the central role for activated PPARδ in the reversal of any tendency toward the development of insulin resistance.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

de Lange, Pieter& Lombardi, Assunta& Silvestri, Elena& Goglia, Fernando& Lanni, Antonia& Moreno, Maria. 2008. Peroxisome Proliferator-Activated Receptor Delta : A Conserved Director of Lipid Homeostasis through Regulation of the Oxidative Capacity of Muscle. PPAR Research،Vol. 2008, no. 2008, pp.1-7.
https://search.emarefa.net/detail/BIM-451678

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

de Lange, Pieter…[et al.]. Peroxisome Proliferator-Activated Receptor Delta : A Conserved Director of Lipid Homeostasis through Regulation of the Oxidative Capacity of Muscle. PPAR Research No. 2008 (2008), pp.1-7.
https://search.emarefa.net/detail/BIM-451678

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

de Lange, Pieter& Lombardi, Assunta& Silvestri, Elena& Goglia, Fernando& Lanni, Antonia& Moreno, Maria. Peroxisome Proliferator-Activated Receptor Delta : A Conserved Director of Lipid Homeostasis through Regulation of the Oxidative Capacity of Muscle. PPAR Research. 2008. Vol. 2008, no. 2008, pp.1-7.
https://search.emarefa.net/detail/BIM-451678

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-451678