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Peroxisome Proliferator-Activated Receptor Delta : A Conserved Director of Lipid Homeostasis through Regulation of the Oxidative Capacity of Muscle
Joint Authors
de Lange, Pieter
Silvestri, Elena
Moreno, Maria
Lanni, Antonia
Lombardi, Assunta
Goglia, Fernando
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-09-22
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
The peroxisome proliferator-activated receptors (PPARs), which are ligand-inducible transcription factors expressed in a variety of tissues, have been shown to perform key roles in lipid homeostasis.
In physiological situations such as fasting and physical exercise, one PPAR subtype, PPARδ, triggers a transcriptional program in skeletal muscle leading to a switch in fuel usage from glucose/fatty acids to solely fatty acids, thereby drastically increasing its oxidative capacity.
The metabolic action of PPARδ has also been verified in humans.
In addition, it has become clear that the action of PPARδ is not restricted to skeletal muscle.
Indeed, PPARδ has been shown to play a crucial role in whole-body lipid homeostasis as well as in insulin sensitivity, and it is active not only in skeletal muscle (as an activator of fat burning) but also in the liver (where it can activate glycolysis/lipogenesis, with the produced fat being oxidized in muscle) and in the adipose tissue (by incrementing lipolysis).
The main aim of this review is to highlight the central role for activated PPARδ in the reversal of any tendency toward the development of insulin resistance.
American Psychological Association (APA)
de Lange, Pieter& Lombardi, Assunta& Silvestri, Elena& Goglia, Fernando& Lanni, Antonia& Moreno, Maria. 2008. Peroxisome Proliferator-Activated Receptor Delta : A Conserved Director of Lipid Homeostasis through Regulation of the Oxidative Capacity of Muscle. PPAR Research،Vol. 2008, no. 2008, pp.1-7.
https://search.emarefa.net/detail/BIM-451678
Modern Language Association (MLA)
de Lange, Pieter…[et al.]. Peroxisome Proliferator-Activated Receptor Delta : A Conserved Director of Lipid Homeostasis through Regulation of the Oxidative Capacity of Muscle. PPAR Research No. 2008 (2008), pp.1-7.
https://search.emarefa.net/detail/BIM-451678
American Medical Association (AMA)
de Lange, Pieter& Lombardi, Assunta& Silvestri, Elena& Goglia, Fernando& Lanni, Antonia& Moreno, Maria. Peroxisome Proliferator-Activated Receptor Delta : A Conserved Director of Lipid Homeostasis through Regulation of the Oxidative Capacity of Muscle. PPAR Research. 2008. Vol. 2008, no. 2008, pp.1-7.
https://search.emarefa.net/detail/BIM-451678
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-451678