Molecular Mechanisms of Liver Injury and Hepatocarcinogenesis : Focusing on the Role of Stress-Activated MAPK
المؤلفون المشاركون
المصدر
Pathology Research International
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-05-14
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Hepatocellular carcinoma (HCC) is the third most common cause of cancer mortality.
Short-term prognosis of patients with HCC has improved recently due to advances in early diagnosis and treatment, but long-term prognosis is still unsatisfactory.
Therefore, obtaining a further understanding of the molecular carcinogenic mechanisms and the unique pathogenic biology of HCC is important.
The most characteristic process in hepatocarcinogenesis is underlying chronic liver injury, which leads to repeated cycles of hepatocyte death, inflammation, and compensatory proliferation and subsequently provides a mitogenic and mutagenic environment leading to the development of HCC.
Recent in vivo studies have shown that the stress-activated mitogen-activated protein kinase (MAPK) cascade converging on c-Jun NH2-terminal kinase (JNK) and p38 plays a central role in these processes, and it has attracted considerable attention as a therapeutic target.
However, JNK and p38 have complex functions and a wide range of cellular effects.
In addition, crosstalk with each other and the nuclear factor-kappaB pathway further complicate these functions.
A full understanding is essential to bring these observations into clinical settings.
In this paper, we discuss the latest findings regarding the mechanisms of liver injury and hepatocarcinogenesis focusing on the role of the stress-activated MAPK pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nakagawa, Hayato& Maeda, Shin. 2012. Molecular Mechanisms of Liver Injury and Hepatocarcinogenesis : Focusing on the Role of Stress-Activated MAPK. Pathology Research International،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-451693
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nakagawa, Hayato& Maeda, Shin. Molecular Mechanisms of Liver Injury and Hepatocarcinogenesis : Focusing on the Role of Stress-Activated MAPK. Pathology Research International No. 2012 (2012), pp.1-14.
https://search.emarefa.net/detail/BIM-451693
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nakagawa, Hayato& Maeda, Shin. Molecular Mechanisms of Liver Injury and Hepatocarcinogenesis : Focusing on the Role of Stress-Activated MAPK. Pathology Research International. 2012. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-451693
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-451693
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر