Fenretinide (4-HPR) : A Preventive Chance for Women at Genetic and Familial Risk?
المؤلفون المشاركون
Feroce, Irene
Varricchio, Clara
Montefrancesco, Chiara
Guerrieri-Gonzaga, Aliana
Cazzaniga, Massimiliano
المصدر
Journal of Biomedicine and Biotechnology
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-03-05
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The incidence and mortality of breast cancer have been recently influenced by several new therapeutic strategies.
In particular our knowledge on cancer precursors, risk biomarkers, and genetics has considerably increased, and prevention strategies are being successfully explored.
Since their discovery, retinoids, the natural and synthetic derivatives of vitamin A, have been known to play a crucial role in cell and tissue differentiation and their ability to inhibit carcinogenesis has made them the ideal chemopreventive agents studied in several preclinical and clinical trials.
Fenretinide (4-HPR) is the most studied retinoid in breast cancer chemoprevention clinical trials due to its selective accumulation in breast tissue and its favorable toxicological profile.
This agent showed a significative reduction of the incidence of second breast tumors in premenopausal women confirmed after 15-year followups.
Considering Fenretinide protective action, a similar trend on ovarian cancer, this drug warrants reevaluations as a preventive agent for high-risk young women, such as BRCA-1 and 2 mutation carriers or with a high familial risk.
This favorable effect therefore provides a strong rationale for a primary prevention trial in these unaffected cohort of women.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cazzaniga, Massimiliano& Varricchio, Clara& Montefrancesco, Chiara& Feroce, Irene& Guerrieri-Gonzaga, Aliana. 2012. Fenretinide (4-HPR) : A Preventive Chance for Women at Genetic and Familial Risk?. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-451694
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cazzaniga, Massimiliano…[et al.]. Fenretinide (4-HPR) : A Preventive Chance for Women at Genetic and Familial Risk?. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-451694
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cazzaniga, Massimiliano& Varricchio, Clara& Montefrancesco, Chiara& Feroce, Irene& Guerrieri-Gonzaga, Aliana. Fenretinide (4-HPR) : A Preventive Chance for Women at Genetic and Familial Risk?. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-451694
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-451694
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر