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Fenretinide (4-HPR) : A Preventive Chance for Women at Genetic and Familial Risk?
Joint Authors
Feroce, Irene
Varricchio, Clara
Montefrancesco, Chiara
Guerrieri-Gonzaga, Aliana
Cazzaniga, Massimiliano
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-05
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The incidence and mortality of breast cancer have been recently influenced by several new therapeutic strategies.
In particular our knowledge on cancer precursors, risk biomarkers, and genetics has considerably increased, and prevention strategies are being successfully explored.
Since their discovery, retinoids, the natural and synthetic derivatives of vitamin A, have been known to play a crucial role in cell and tissue differentiation and their ability to inhibit carcinogenesis has made them the ideal chemopreventive agents studied in several preclinical and clinical trials.
Fenretinide (4-HPR) is the most studied retinoid in breast cancer chemoprevention clinical trials due to its selective accumulation in breast tissue and its favorable toxicological profile.
This agent showed a significative reduction of the incidence of second breast tumors in premenopausal women confirmed after 15-year followups.
Considering Fenretinide protective action, a similar trend on ovarian cancer, this drug warrants reevaluations as a preventive agent for high-risk young women, such as BRCA-1 and 2 mutation carriers or with a high familial risk.
This favorable effect therefore provides a strong rationale for a primary prevention trial in these unaffected cohort of women.
American Psychological Association (APA)
Cazzaniga, Massimiliano& Varricchio, Clara& Montefrancesco, Chiara& Feroce, Irene& Guerrieri-Gonzaga, Aliana. 2012. Fenretinide (4-HPR) : A Preventive Chance for Women at Genetic and Familial Risk?. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-451694
Modern Language Association (MLA)
Cazzaniga, Massimiliano…[et al.]. Fenretinide (4-HPR) : A Preventive Chance for Women at Genetic and Familial Risk?. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-451694
American Medical Association (AMA)
Cazzaniga, Massimiliano& Varricchio, Clara& Montefrancesco, Chiara& Feroce, Irene& Guerrieri-Gonzaga, Aliana. Fenretinide (4-HPR) : A Preventive Chance for Women at Genetic and Familial Risk?. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-451694
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-451694