Dexamethasone Treatment Reverses Cognitive Impairment but Increases Brain Oxidative Stress in Rats Submitted to Pneumococcal Meningitis
المؤلفون المشاركون
Barichello, Tatiana
Dal-Pizzol, Felipe
Santos, Ana Lucia B.
Generoso, Jaqueline S.
Petronilho, Fabricia
Comim, Clarissa M.
Quevedo, João
Cipriano, Andreza L.
Silvestre, Cintia
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-11-21
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الأحياء
الملخص EN
Pneumococcal meningitis is associated with a significant mortality rate and neurologic sequelae.
The animals received either 10 μL of saline or a S.
pneumoniae suspension and were randomized into different groups: sham: placebo with dexamethasone 0.7 mg/kg/1 day; placebo with dexamethasone 0.2 mg/kg/7 days; meningitis groups: dexamethasone 0.7 mg/kg/1 day and dexamethasone 0.2 mg/kg/7 days.
Ten days after induction we evaluated memory and oxidative stress parameters in hippocampus and cortex.
In the step-down inhibitory avoidance task, we observed memory impairment in the meningitis group with dexamethasone 0.2 mg/kg/7 days.
The lipid peroxidation was increased in hippocampus in the meningitis groups with dexamethasone and in cortex only in the meningitis group with dexamethasone 0.2 mg/kg/7 days.
The protein carbonyl was increased in hippocampus in the meningitis groups with dexamethasone and in cortex in the meningitis groups with and without dexamethasone.
There was a decrease in the proteins integrity in hippocampus in all groups receiving treatment with dexamethasone and in cortex in all groups with dexamethasone (0.7 mg/kg/1 day).
The mitochondrial superoxide was increased in the hippocampus and cortex in the meningitis group with dexamethasone 0.2 mg/kg/7 days.
Our findings demonstrate that dexamethasone reverted cognitive impairment but increased brain oxidative stress in hippocampus and cortex in Wistar rats ten days after pneumococcal meningitis induction.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Barichello, Tatiana& Santos, Ana Lucia B.& Silvestre, Cintia& Generoso, Jaqueline S.& Cipriano, Andreza L.& Petronilho, Fabricia…[et al.]. 2011. Dexamethasone Treatment Reverses Cognitive Impairment but Increases Brain Oxidative Stress in Rats Submitted to Pneumococcal Meningitis. Oxidative Medicine and Cellular Longevity،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-451709
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Barichello, Tatiana…[et al.]. Dexamethasone Treatment Reverses Cognitive Impairment but Increases Brain Oxidative Stress in Rats Submitted to Pneumococcal Meningitis. Oxidative Medicine and Cellular Longevity No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-451709
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Barichello, Tatiana& Santos, Ana Lucia B.& Silvestre, Cintia& Generoso, Jaqueline S.& Cipriano, Andreza L.& Petronilho, Fabricia…[et al.]. Dexamethasone Treatment Reverses Cognitive Impairment but Increases Brain Oxidative Stress in Rats Submitted to Pneumococcal Meningitis. Oxidative Medicine and Cellular Longevity. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-451709
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-451709
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر