Dexamethasone Treatment Reverses Cognitive Impairment but Increases Brain Oxidative Stress in Rats Submitted to Pneumococcal Meningitis
Joint Authors
Barichello, Tatiana
Dal-Pizzol, Felipe
Santos, Ana Lucia B.
Generoso, Jaqueline S.
Petronilho, Fabricia
Comim, Clarissa M.
Quevedo, João
Cipriano, Andreza L.
Silvestre, Cintia
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-21
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Pneumococcal meningitis is associated with a significant mortality rate and neurologic sequelae.
The animals received either 10 μL of saline or a S.
pneumoniae suspension and were randomized into different groups: sham: placebo with dexamethasone 0.7 mg/kg/1 day; placebo with dexamethasone 0.2 mg/kg/7 days; meningitis groups: dexamethasone 0.7 mg/kg/1 day and dexamethasone 0.2 mg/kg/7 days.
Ten days after induction we evaluated memory and oxidative stress parameters in hippocampus and cortex.
In the step-down inhibitory avoidance task, we observed memory impairment in the meningitis group with dexamethasone 0.2 mg/kg/7 days.
The lipid peroxidation was increased in hippocampus in the meningitis groups with dexamethasone and in cortex only in the meningitis group with dexamethasone 0.2 mg/kg/7 days.
The protein carbonyl was increased in hippocampus in the meningitis groups with dexamethasone and in cortex in the meningitis groups with and without dexamethasone.
There was a decrease in the proteins integrity in hippocampus in all groups receiving treatment with dexamethasone and in cortex in all groups with dexamethasone (0.7 mg/kg/1 day).
The mitochondrial superoxide was increased in the hippocampus and cortex in the meningitis group with dexamethasone 0.2 mg/kg/7 days.
Our findings demonstrate that dexamethasone reverted cognitive impairment but increased brain oxidative stress in hippocampus and cortex in Wistar rats ten days after pneumococcal meningitis induction.
American Psychological Association (APA)
Barichello, Tatiana& Santos, Ana Lucia B.& Silvestre, Cintia& Generoso, Jaqueline S.& Cipriano, Andreza L.& Petronilho, Fabricia…[et al.]. 2011. Dexamethasone Treatment Reverses Cognitive Impairment but Increases Brain Oxidative Stress in Rats Submitted to Pneumococcal Meningitis. Oxidative Medicine and Cellular Longevity،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-451709
Modern Language Association (MLA)
Barichello, Tatiana…[et al.]. Dexamethasone Treatment Reverses Cognitive Impairment but Increases Brain Oxidative Stress in Rats Submitted to Pneumococcal Meningitis. Oxidative Medicine and Cellular Longevity No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-451709
American Medical Association (AMA)
Barichello, Tatiana& Santos, Ana Lucia B.& Silvestre, Cintia& Generoso, Jaqueline S.& Cipriano, Andreza L.& Petronilho, Fabricia…[et al.]. Dexamethasone Treatment Reverses Cognitive Impairment but Increases Brain Oxidative Stress in Rats Submitted to Pneumococcal Meningitis. Oxidative Medicine and Cellular Longevity. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-451709
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-451709