Effects of Long-Term Treatment with Ranirestat, a Potent Aldose Reductase Inhibitor, on Diabetic Cataract and Neuropathy in Spontaneously Diabetic Torii Rats
المؤلفون المشاركون
Kakehashi, Akihiro
Kawakami, Masanobu
Toyoda, Fumihiko
Fujimoto, Wilfred Y.
Kanazawa, Yasunori
Takano, Hiroko
Shinmura, Machiko
Matsumoto, Takafumi
Tsuji, Junichi
Ota, Ayumi
Dobashi, Yoh
Obata, Hiroto
Kinoshita, Nozomi
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-03-13
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
We evaluated ranirestat, an aldose reductase inhibitor, in diabetic cataract and neuropathy (DN) in spontaneously diabetic Torii (SDT) rats compared with epalrestat, the positive control.
Animals were divided into groups and treated once daily with oral ranirestat (0.1, 1.0, 10 mg/kg) or epalrestat (100 mg/kg) for 40 weeks, normal Sprague-Dawley rats, and untreated SDT rats.
Lens opacification was scored from 0 (normal) to 3 (mature cataract).
The combined scores (0–6) from both lenses represented the total for each animal.
DN was assessed by measuring the motor nerve conduction velocity (MNCV) in the sciatic nerve.
Sorbitol and fructose levels were measured in the lens and sciatic nerve 40 weeks after diabetes onset.
Cataracts developed more in untreated rats than normal rats (P<0.01).
Ranirestat significantly (P<0.01) inhibited rapid cataract development; epalrestat did not.
Ranirestat significantly reversed the MNCV decrease (40.7 ± 0.6 m/s) in SDT rats dose-dependently (P<0.01).
Epalrestat also reversed the prevented MNCV decrease (P<0.05).
Sorbitol levels in the sciatic nerve increased significantly in SDT rats (2.05 ± 0.10 nmol/g), which ranirestat significantly suppressed dose-dependently, (P<0.05, <0.01, and <0.01); epalrestat did not.
Ranirestat prevents DN and cataract; epalrestat prevents DN only.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ota, Ayumi& Kakehashi, Akihiro& Toyoda, Fumihiko& Kinoshita, Nozomi& Shinmura, Machiko& Takano, Hiroko…[et al.]. 2013. Effects of Long-Term Treatment with Ranirestat, a Potent Aldose Reductase Inhibitor, on Diabetic Cataract and Neuropathy in Spontaneously Diabetic Torii Rats. Journal of Diabetes Research،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-451988
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ota, Ayumi…[et al.]. Effects of Long-Term Treatment with Ranirestat, a Potent Aldose Reductase Inhibitor, on Diabetic Cataract and Neuropathy in Spontaneously Diabetic Torii Rats. Journal of Diabetes Research No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-451988
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ota, Ayumi& Kakehashi, Akihiro& Toyoda, Fumihiko& Kinoshita, Nozomi& Shinmura, Machiko& Takano, Hiroko…[et al.]. Effects of Long-Term Treatment with Ranirestat, a Potent Aldose Reductase Inhibitor, on Diabetic Cataract and Neuropathy in Spontaneously Diabetic Torii Rats. Journal of Diabetes Research. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-451988
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-451988
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر