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Effects of Long-Term Treatment with Ranirestat, a Potent Aldose Reductase Inhibitor, on Diabetic Cataract and Neuropathy in Spontaneously Diabetic Torii Rats
Joint Authors
Kakehashi, Akihiro
Kawakami, Masanobu
Toyoda, Fumihiko
Fujimoto, Wilfred Y.
Kanazawa, Yasunori
Takano, Hiroko
Shinmura, Machiko
Matsumoto, Takafumi
Tsuji, Junichi
Ota, Ayumi
Dobashi, Yoh
Obata, Hiroto
Kinoshita, Nozomi
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-13
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
We evaluated ranirestat, an aldose reductase inhibitor, in diabetic cataract and neuropathy (DN) in spontaneously diabetic Torii (SDT) rats compared with epalrestat, the positive control.
Animals were divided into groups and treated once daily with oral ranirestat (0.1, 1.0, 10 mg/kg) or epalrestat (100 mg/kg) for 40 weeks, normal Sprague-Dawley rats, and untreated SDT rats.
Lens opacification was scored from 0 (normal) to 3 (mature cataract).
The combined scores (0–6) from both lenses represented the total for each animal.
DN was assessed by measuring the motor nerve conduction velocity (MNCV) in the sciatic nerve.
Sorbitol and fructose levels were measured in the lens and sciatic nerve 40 weeks after diabetes onset.
Cataracts developed more in untreated rats than normal rats (P<0.01).
Ranirestat significantly (P<0.01) inhibited rapid cataract development; epalrestat did not.
Ranirestat significantly reversed the MNCV decrease (40.7 ± 0.6 m/s) in SDT rats dose-dependently (P<0.01).
Epalrestat also reversed the prevented MNCV decrease (P<0.05).
Sorbitol levels in the sciatic nerve increased significantly in SDT rats (2.05 ± 0.10 nmol/g), which ranirestat significantly suppressed dose-dependently, (P<0.05, <0.01, and <0.01); epalrestat did not.
Ranirestat prevents DN and cataract; epalrestat prevents DN only.
American Psychological Association (APA)
Ota, Ayumi& Kakehashi, Akihiro& Toyoda, Fumihiko& Kinoshita, Nozomi& Shinmura, Machiko& Takano, Hiroko…[et al.]. 2013. Effects of Long-Term Treatment with Ranirestat, a Potent Aldose Reductase Inhibitor, on Diabetic Cataract and Neuropathy in Spontaneously Diabetic Torii Rats. Journal of Diabetes Research،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-451988
Modern Language Association (MLA)
Ota, Ayumi…[et al.]. Effects of Long-Term Treatment with Ranirestat, a Potent Aldose Reductase Inhibitor, on Diabetic Cataract and Neuropathy in Spontaneously Diabetic Torii Rats. Journal of Diabetes Research No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-451988
American Medical Association (AMA)
Ota, Ayumi& Kakehashi, Akihiro& Toyoda, Fumihiko& Kinoshita, Nozomi& Shinmura, Machiko& Takano, Hiroko…[et al.]. Effects of Long-Term Treatment with Ranirestat, a Potent Aldose Reductase Inhibitor, on Diabetic Cataract and Neuropathy in Spontaneously Diabetic Torii Rats. Journal of Diabetes Research. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-451988
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-451988